Genetic propensity for cerebral amyloidosis and risk of mild cognitive impairment and Alzheimer's disease within a cognitive reserve framework-Reference-Cited by-同舟云学术

Genetic propensity for cerebral amyloidosis and risk of mild cognitive impairment and Alzheimer's disease within a cognitive reserve framework

Published:2023-03-09 Issue:9 Volume:19 Page:3794-3805
ISSN:1552-5260
Container-title:Alzheimer's & Dementia
language:en
Short-container-title:Alzheimer's & Dementia

Author:

Mourtzi Niki¹,Charisis Sokratis¹²,Tsapanou Angeliki¹³,Ntanasi Eva¹⁴,Hatzimanolis Alexandros⁵,Ramirez Alfredo⁶⁷⁸⁹¹⁰,Heilmann‐Heimbach Stefanie¹¹,Grenier‐Boley Benjamin¹²,Lambert Jean‐Charles¹²,Yannakoulia Mary⁴,Kosmidis Mary¹³,Dardiotis Efthimios¹⁴,Hadjigeorgiou Georgiios¹⁵,Sakka Paraskevi¹⁶,Georgakis Marios¹⁷¹⁸¹⁹,Yaakov Stern³,Scarmeas Nikolaos¹³

Affiliation:

1. 1st Department of Neurology Aiginition Hospital, National and Kapodistrian University of Athens Medical School Athens Greece

2. Department of Neurology University of Texas Health Science Center at San Antonio San Antonio Texas USA

3. Department of Neurology, The Gertrude H. Sergievsky Center Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Columbia University New York New York USA

4. Department of Nutrition and Dietetics Harokopio University Athens Greece

5. Department of Psychiatry National and Kapodistrian University of Athens Medical School, Eginition Hospital Athens Greece

6. Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy Medical Faculty University of Cologne Cologne Germany

7. Department of Neurodegenerative Diseases and Geriatric Psychiatry University Hospital Bonn Bonn Germany

8. German Center for Neurodegenerative Diseases (DZNE Bonn) Bonn Germany

9. Department of Psychiatry Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases San Antonio Texas USA

10. Excellence Cluster on Cellular Stress Responses in Aging‐Associated Diseases (CECAD) University of Cologne Cologne Germany

11. Institute of Human Genetics University of Bonn, School of Medicine & University Hospital Bonn Bonn Germany

12. Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille U1167‐RID‐AGE facteurs de risque et déterminants moléculaires des maladies liés au vieillissement Lille France

13. Lab of Cognitive Neuroscience, School of Psychology Aristotle University of Thessaloniki Thessaloniki Greece

14. Department of Neurology, University Hospital of Larissa Faculty of Medicine School of Health Sciences University of Thessaly Larissa Greece

15. Department of Neurology Medical School University of Cyprus Nicosia Cyprus

16. Athens Association of Alzheimer's Disease and Related Disorders Marousi Greece

17. Center for Genomic Medicine Massachusetts General Hospital Boston Massachusetts USA

18. Program in Medical and Population Genetics Broad Institute of Harvard and the Massachusetts Institute of Technology Boston Massachusetts USA

19. Institute for Stroke and Dementia Research (ISD), University Hospital Ludwig‐Maximilians‐University (LMU) Munich Munich Germany

Abstract

AbstractINTRODUCTIONWe constructed a polygenic risk score (PRS) for β‐amyloid (PRSAβ42) to proxy AD pathology and investigated its association with incident Alzheimer's disease (AD)/amnestic mild cognitive impairment (aMCI) and the influence of cognitive reserve (CR), proxied by educational years, on the relationship between PRSAβ42 and AD/aMCI risk.METHODSA total of 618 cognitive‐normal participants were followed‐up for 2.92 years. The association of PRSAβ42 and CR with AD/aMCI incidence was examined with COX models. Then we examined the additive interaction between PRSAβ42 and CR and the CR effect across participants with different PRSAβ42 levels.RESULTSHigher PRSAβ42 and CR were associated with a 33.9% higher risk and 8.3% less risk for AD/aMCI, respectively. An additive interaction between PRSAβ42 and CR was observed. High CR was associated with 62.6% less risk of AD/aMCI incidence only in the high‐PRSAβ42 group.DISCUSSIONA super‐additive effect of PRSAβ42 and CR on AD/aMCI risk was observed. CR influence was evident in participants with high PRSAβ42.

Funder

Alzheimer's Association

Publisher

Wiley

Subject

Psychiatry and Mental health,Cellular and Molecular Neuroscience,Geriatrics and Gerontology,Neurology (clinical),Developmental Neuroscience,Health Policy,Epidemiology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/alz.12980

Reference72 articles.

1. Whitepaper: Defining and investigating cognitive reserve, brain reserve, and brain maintenance

2. Cognitive Reserve and Lifestyle

3. Cognitive Reserve–Mediated Modulation of Positron Emission Tomographic Activations During Memory Tasks in Alzheimer Disease

4. Influence of leisure activity on the incidence of Alzheimer's Disease

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