Responsive Versus Continuous Deep Brain Stimulation for Speech in Essential Tremor: A Pilot Study

Author:

Cernera Stephanie1ORCID,Long Sarah1,Kelberman Madison1,Hegland Karen W.2,Hicks Julie3,Smith‐Hublou May2,Taylor Bryn2,Mou Yuhan2,de Hemptinne Coralie4,Johnson Kara A.4,Cagle Jackson N.4,Moore Kathryn5,Foote Kelly D.6,Okun Michael S.4,Gunduz Aysegul14

Affiliation:

1. J. Crayton Pruitt Department of Biomedical Engineering Gainesville Florida USA

2. Department of Speech, Language, and Hearing Sciences Norman Fixel Institute for Neurological Diseases Gainesville Florida USA

3. Department of Neurologic Rehabilitation Stanford Neuroscience Health Center Palo Alto California USA

4. Department of Neurology Norman Fixel Institute for Neurological Diseases Gainesville Florida USA

5. Department of Neurology Duke University Durham North Carolina USA

6. Department of Neurosurgery Norman Fixel Institute for Neurological Diseases Gainesville Florida USA

Abstract

AbstractBackgroundResponsive deep brain stimulation (rDBS) uses physiological signals to deliver stimulation when needed. rDBS is hypothesized to reduce stimulation‐induced speech effects associated with continuous DBS (cDBS) in patients with essential tremor (ET).ObjectiveTo determine if rDBS reduces cDBS speech‐related side effects while maintaining tremor suppression.MethodsEight ET participants with thalamic DBS underwent unilateral rDBS. Both speech evaluations and tremor severity were assessed across three conditions (DBS OFF, cDBS ON, and rDBS ON). Speech was analyzed using intelligibility ratings. Tremor severity was scored using the Fahn‐Tolosa‐Marin Tremor Rating Scale (TRS).ResultsDuring unilateral cDBS, participants experienced reduced speech intelligibility (P = 0.025) compared to DBS OFF. rDBS was not associated with a deterioration of intelligibility. Both rDBS (P = 0.026) and cDBS (P = 0.038) improved the contralateral TRS score compared to DBS OFF.ConclusionsrDBS maintained speech intelligibility without loss of tremor suppression. A larger prospective chronic study of rDBS in ET is justified. © 2024 International Parkinson and Movement Disorder Society.

Funder

National Institute of Neurological Disorders and Stroke

Publisher

Wiley

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3