Alveolar Soft Tissue Sarcoma: Correlation of MRI Features With Histological Grading and Patient Prognosis

Author:

Yuan Junhui12,Xie Deshun3,Fang Shaobo4ORCID,Meng Fan1,Shan Dongqiu1,Wang Yuanyuan5,Du Xinhui6,Xu Chunmiao1ORCID,Zhang Renzhi7,Chen Xuejun1ORCID

Affiliation:

1. Department of Medical Imaging The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital Zhengzhou Henan China

2. Department of Radiology The First Affiliated Hospital of Fujian Medical University Fuzhou Fujian China

3. Department of Radiology Heze Municipal Hospital Heze Shandong China

4. Department of Medical Imaging Zhengzhou University People's Hospital & Henan Provincial People's Hospital, Academy of Medical Sciences, Zhengzhou University Zhengzhou Henan China

5. Department of Pathology The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital Zhengzhou Henan China

6. Department of Bone and Soft Tissue The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital Zhengzhou Henan China

7. National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China

Abstract

BackgroundAlveolar Soft Part Sarcoma (ASPS) is a rare, aggressive cancer whose diagnosis and treatment depend on histological grading. However, tumor variability can lead to underestimation, affecting treatment, and patient survival.ObjectiveTo evaluate MRI features associated with Grade III ASPS and to determine the relationship between MRI features and patient prognosis.Study TypeRetrospective analysis.SubjectsSixty‐seven patients with ASPS were included with 37 males and 30 females (M/F = 1.23) follow‐up and survival analysis on 50 patients.Field Strength/SequenceA 3.0 T, T1WI‐FSE, T2WI‐FSE, DWI‐EPI, DCE‐MRI (gradient echo).AssessmentMRI features (margin, peritumoral oedema, peritumoral enhancement, necrosis, vascular flow void signal, heterogeneous signal intensity [SI] at T1WI and T2WI, ADCmean, time‐intensity curve [TIC] type, distant metastasis, and bone invasion) and histological grading were independently evaluated by three radiologists and two pathologists, with Grade III considered high‐grade.Statistical TestsThe chi‐square or Fisher's exact test was used to assess the correlation between MRI features and histological grading. Multivariable binary logistic regression identified independent factors associated with high‐grade tumors. The Kaplan–Meier method and Cox proportional hazards model were used to calculate hazard ratios for MRI features.ResultsTumor necrosis, heterogeneous SI at T2WI ≥50%, and ADCmean were associated with high‐grade ASPS. Tumor necrosis was an independent factors associated with local relapse‐free survival (odds ratio [OR], 3.88). TIC type was associated with 5‐year survival rate (OR, 2.80) and local relapse‐free survival (OR, 2.69). Heterogeneous SI at T2WI ≥50% was associated with 5‐year survival (OR, 4.00), local relapse‐free survival (OR, 5.58), and local relapse‐free survival (OR, 4.84).Data ConclusionMRI features including tumor necrosis, heterogeneity of SI at T2WI, ADCmean, and TIC type aid in assessing ASPS grading and prognosis.Evidence Level4Technical EfficacyStage 5

Publisher

Wiley

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3