Evaluation of the effect of sodium–glucose co‐transporter 2 inhibition with empagliflozin on morbidity and mortality of patients with chronic heart failure and a reduced ejection fraction: rationale for and design of the EMPEROR‐Reduced trial

Author:

Packer Milton12,Butler Javed3,Filippatos Gerasimos S.45,Jamal Waheed6,Salsali Afshin7,Schnee Janet7,Kimura Karen8,Zeller Cordula9,George Jyothis6,Brueckmann Martina610,Anker Stefan D.11,Zannad Faiez12,Packer Milton,Anker Stefan D.,Butler Javed,Filippatos Gerasimos,Zannad Faiez,George Jyothis,Brueckmann Martina,Perrone Sergio,Nicholls Stephen,Janssens Stefan,Bocchi Edmar,Giannetti Nadia,Verma Subodh,Jian Zhang,Spinar Jindrich,Seronde Marie‐France,Böhm Michael,Merkely Bela,Chopra Vijay,Senni Michele,Taddei Stefano,Tsutsui Hiroyuki,Choi Dong‐Ju,Chuquiure Eduardo,La Rocca Hans Pieter Brunner,Ponikowski Piotr,Juanatey Jose Ramon Gonzalez,Squire Iain,Butler Javed,Januzzi James,Pina Ileana,Pocock Stuart J.,Carson Peter,Doehner Wolfram,Miller Alan,Haas Markus,Pehrson Steen,Komajda Michel,Anand Inder,Teerlink John,Rabinstein Alejandro,Steiner Thorsten,Kamel Hooman,Tsivgoulis Georgios,Lewis James,Freston James,Kaplowitz Neil,Mann Johannes,Petrie Mark,Bernstein Richard,Cheung Alfred,Green Jennifer,Januzzi James,Kaul Sanjay,Ping Carolyn Lam Su,Lip Gregory,Marx Nikolaus,McCullough Peter,Mehta Cyrus,Ponikowski Piotr,Rosenstock Julio,Sattar Naveed,Scirica Benjamin,Tsutsui Hiroyuki,Verma Subodh,Wanner Christoph,Welty Francine K.,Parhofer Klaus G.,Clayton Tim,Pedersen Terje R.,Lees Kennedy R.,Konstam Marvin A.,Greenberg Barry,Palmer Mike, , , , , , ,

Affiliation:

1. Baylor Heart and Vascular Institute Baylor University Medical Center Dallas TX USA

2. Imperial College London UK

3. University of Mississippi School of Medicine Jackson MI USA

4. Department of Cardiology National and Kapodistrian University of Athens Athens Greece

5. School of Medicine Athens University Hospital Attikon Athens Greece

6. Boehringer Ingelheim International GmbH Ingelheim Germany

7. Boehringer Ingelheim Pharmaceuticals Ridgefield CT USA

8. Boehringer Ingelheim Canada Ltd. Burlington Canada

9. Boehringer Ingelheim Pharma GmbH & Co. KG Biberach Germany

10. Faculty of Medicine Mannheim University of Heidelberg Mannheim Germany

11. Department of Cardiology (CVK); and Berlin Institute of Health Center for Regenerative Therapies (BCRT); German Centre for Cardiovascular Research (DZHK) partner site, Berlin, Germany Charité Universitätsmedizin Berlin Berlin Germany

12. Inserm INI‐CRCT, CHRU Université de Lorraine Nancy France

Publisher

Wiley

Subject

Cardiology and Cardiovascular Medicine

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