Radiation Resistance of Cancer Stem Cells: The 4 R's of Radiobiology Revisited

Author:

Pajonk Frank12,Vlashi Erina1,McBride William H.12

Affiliation:

1. Department of Radiation Oncology, Division of Molecular and Cellular Oncology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA

2. Jonsson Comprehensive Cancer Center at UCLA, Los Angeles, California, USA

Abstract

Abstract There is compelling evidence that many solid cancers are organized hierarchically and contain a small population of cancer stem cells (CSCs). It seems reasonable to suggest that a cancer cure can be achieved only if this population is eliminated. Unfortunately, there is growing evidence that CSCs are inherently resistant to radiation, and perhaps other cancer therapies. In general, success or failure of standard clinical radiation treatment is determined by the 4 R's of radiobiology: repair of DNA damage, redistribution of cells in the cell cycle, repopulation, and reoxygenation of hypoxic tumor areas. We relate recent findings on CSCs to these four phenomena and discuss possible consequences.

Funder

California Breast Cancer Research Program

Department of Defense

National Cancer Institute

Biomedical Advance Research and Development Authority

Publisher

Oxford University Press (OUP)

Subject

Cell Biology,Developmental Biology,Molecular Medicine

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