Causal relationships between body mass index, smoking and lung cancer: Univariable and multivariable Mendelian randomization

Author:

Zhou Wen12,Liu Geoffrey3,Hung Rayjean J.45,Haycock Philip C.67,Aldrich Melinda C.8,Andrew Angeline S.9,Arnold Susanne M.10,Bickeböller Heike11,Bojesen Stig E.12ORCID,Brennan Paul13ORCID,Brunnström Hans14,Melander Olle14,Caporaso Neil E.15,Landi Maria Teresa15,Chen Chu16ORCID,Goodman Gary E.16,Christiani David C.17,Cox Angela18,Field John K.19,Johansson Mikael20,Kiemeney Lambertus A.21,Lam Stephen22,Lazarus Philip23,Le Marchand Loïc24,Rennert Gad25,Risch Angela26272829,Schabath Matthew B.30,Shete Sanjay S.31,Tardón Adonina32,Zienolddiny Shanbeh33,Shen Hongbing1ORCID,Amos Christopher I.2ORCID

Affiliation:

1. Department of Epidemiology, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine Nanjing Medical University Nanjing China

2. Institute for Clinical and Translational Research Baylor College of Medicine Houston Texas USA

3. Princess Margaret Cancer Center University Health Network Toronto Ontario Canada

4. Prosserman Centre for Population Health Research, Lunenfeld‐Tanenbaum Research Institute, Sinai Health System Toronto Ontario Canada

5. Epidemiology Division, Dalla Lana School of Public Health University of Toronto Toronto Ontario Canada

6. MRC Integrative Epidemiology Unit University of Bristol Bristol UK

7. Bristol Medical School, Population Health Sciences University of Bristol Bristol UK

8. Department of Thoracic Surgery and Division of Epidemiology Vanderbilt University Medical Center Nashville Tennessee USA

9. Department of Epidemiology, Geisel School of Medicine Dartmouth College Hanover New Hampshire USA

10. Markey Cancer Center University of Kentucky Lexington Kentucky USA

11. Department of Genetic Epidemiology University Medical Center, Georg‐August‐Universität Göttingen Göttingen Germany

12. Department of Clinical Biochemistry, Herlev and Gentofte Hospital Copenhagen University Hospital Herlev Denmark

13. Genetic Epidemology Group, International Agency for Research on Cancer Lyon France

14. Clinical Sciences Lund University Lund Sweden

15. Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda Maryland USA

16. Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center and Department of Epidemiology, School of Public Health University of Washington Seattle WA USA

17. Departments of Environmental Health and Epidemiology Harvard T.H. Chan School of Public Health Boston Massachusetts USA

18. Academic Unit of Clinical Oncology University of Sheffield Sheffield UK

19. Department of Molecular and Clinical Cancer Medicine, Roy Castle Lung Cancer Research Programme The University of Liverpool Cancer Research Centre Liverpool UK

20. Department of Radiation Sciences Umeå University Umea Sweden

21. Department for Health Evidence Radboud University Medical Center Nijmegen The Netherlands

22. Department of Integrative Oncology British Columbia Cancer Agency Vancouver British Columbia Canada

23. Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences Washington State University Spokane Washington USA

24. Epidemiology Program University of Hawaii Cancer Center Honolulu Hawaii USA

25. Department of Community Medicine and Epidemiology Carmel Medical Center and Bruce Rappaport Faculty of Medicine, Technion‐Israel Institute of Technology and Clalit National Cancer Control Center Haifa Israel

26. Department of Biosciences, Allergy‐Cancer‐BioNano Research Centre University of Salzburg Salzburg Austria

27. Cancer Cluster Salzburg University of Salzburg Salzburg Austria

28. Division of Cancer Epigenomics DKFZ – German Cancer Research Center Heidelberg Germany

29. Translational Lung Research Center Heidelberg (TLRC), Member of the German Center for Lung Research (DZL) Heidelberg Germany

30. Department of Cancer Epidemiology H. Lee Moffitt Cancer Center and Research Institute Tampa Florida USA

31. Department of Biostatistics, Division of Basic Sciences The University of Texas MD Anderson Cancer Center Houston Texas USA

32. Faculty of Medicine University of Oviedo and ISPA and CIBERESP Oviedo Spain

33. The National Institute of Occupational Health (STAMI) Oslo Norway

Funder

Cancer Prevention and Research Institute of Texas

Cancer Research UK

Foundation for the National Institutes of Health

Publisher

Wiley

Subject

Cancer Research,Oncology

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