Emergency use of uridine triacetate for the prevention and treatment of life-threatening 5-fluorouracil and capecitabine toxicity

Author:

Ma Wen Wee1,Saif Muhammad Wasif2,El-Rayes Bassel F.3,Fakih Marwan G.4,Cartwright Thomas H.5,Posey James A.6,King Thomas R.7,von Borstel Reid W.8,Bamat Michael K.8

Affiliation:

1. Department of Oncology; Mayo Clinic; Rochester Minnesota

2. GI Oncology Program; Tufts University School of Medicine; Boston Massachusetts

3. Department of Hematology and Oncology, Winship Cancer Institute; Emory University; Atlanta Georgia

4. Department of Medical Oncology; City of Hope Medical Center; Duarte California

5. Medical Oncology and Hematology; Florida Cancer Affiliates; Ocala Florida

6. Department of Medical Oncology; Thomas Jefferson University; Philadelphia Pennsylvania

7. BTG International, Inc; West Conshohocken Pennsylvania

8. Wellstat Therapeutics Corporation; Gaithersburg Maryland

Publisher

Wiley

Subject

Cancer Research,Oncology

Reference57 articles.

1. ISMP Canada Fluorouracil incident root cause analysis 2007 http://www.ismp-canada.org/download/reports/FluorouracilIncidentMay2007.pdf

2. Fluorouracil overdose: clinical manifestations and comprehensive management during and after hospitalization;Andreica;J Hematol Oncol Pharm.,2015

3. Fluorouracil error ends tragically, but application of lessons learned will save lives;ISMP Canada;ISMP Med Saf Alert.,2007

4. Characteristics of medication errors with parenteral cytotoxic drugs;Fyhr;Eur J Cancer Care.,2012

5. Alteplase and tenecteplase confusion; lack of E-prescribing interoperability leads to double dosing; accidental overdoses involving fluorouracil infusions;Cohen;Hosp Pharm.,2015

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