Assessing the performance of in silico methods for predicting the pathogenicity of variants in the gene CHEK2, among Hispanic females with breast cancer

Author:

Voskanian Alin1ORCID,Katsonis Panagiotis2ORCID,Lichtarge Olivier23,Pejaver Vikas45ORCID,Radivojac Predrag6ORCID,Mooney Sean D.4ORCID,Capriotti Emidio7,Bromberg Yana8910,Wang Yanran8,Miller Max8ORCID,Martelli Pier Luigi11,Savojardo Castrense11,Babbi Giulia11,Casadio Rita11,Cao Yue12,Sun Yuanfei12,Shen Yang12ORCID,Garg Aditi13,Pal Debnath13ORCID,Yu Yao14,Huff Chad D.14,Tavtigian Sean V.15ORCID,Young Erin15,Neuhausen Susan L.16,Ziv Elad17,Pal Lipika R.18,Andreoletti Gaia19ORCID,Brenner Steven E.19ORCID,Kann Maricel G.1ORCID

Affiliation:

1. Department of Biological SciencesUniversity of Maryland Baltimore Maryland

2. Department of Molecular and Human GeneticsBaylor College of Medicine Houston Texas

3. Department of Pharmacology, Computational and Integrative Biomedical Research CenterBaylor College of Medicine Houston Texas

4. Department of Biomedical Informatics and Medical EducationUniversity of Washington Seattle Washington

5. The eScience InstituteUniversity of Washington Seattle Washington

6. Khoury College of Computer and Information SciencesNortheastern University Boston Massachusetts

7. BioFolD Unit, Department of Pharmacy and Biotechnology (FaBiT)University of Bologna Bologna Italy

8. Department of Biochemistry and MicrobiologyRutgers University New Brunswick New Jersey

9. Department of GeneticsRutgers University New Brunswick New Jersey

10. Institute for Advanced StudyTechnical University of Munich Garching Germany

11. Biocomputing Group, BiGeA/Giorgio Prodi Interdepartmental Center for Cancer ResearchUniversity of Bologna Bologna Italy

12. Department of Electrical and Computer EngineeringTexas A&M University College Station Texas

13. Department of Computational and Data SciencesIndian Institute of Science Bengaluru India

14. Department of EpidemiologyUniversity of Texas MD Anderson Cancer Center Houston Texas

15. Huntsman Cancer InstituteUniversity of Utah School of Medicine Salt Lake City Utah

16. Department of Population SciencesBeckman Research Institute of City of Hope Duarte California

17. Division of General Internal Medicine, Department of Medicine, Institute of Human Genetics, Helen Diller Family Comprehensive Cancer CenterUniversity of California San Francisco California

18. Institute for Bioscience and Biotechnology ResearchUniversity of Maryland Rockville Maryland

19. Department of Plant and Microbial BiologyUniversity of California Berkeley California

Funder

National Institutes of Health

Andrew Sabin Family Foundation

Publisher

Wiley

Subject

Genetics(clinical),Genetics

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