Affiliation:
1. Hunan International Scientific and Technological Cooperation Base of Neurodegenerative and Neurogenetic Diseases Xiangya Hospital Central South University Changsha China
2. Department of Biology Emory University Atlanta Georgia USA
3. Department of Neurology Xiangya Hospital Central South University Changsha China
4. National Clinical Research Center for Geriatric Disorders Xiangya Hospital Central South University Changsha China
5. Engineering Research Center of Hunan Province in Cognitive Impairment Disorders Central South University Changsha China
6. Institute of Software Chinese Academy of Sciences Beijing China
7. School of Computer Science and Technology University of Chinese Academy of Sciences Beijing China
8. Department of Neurology Liuyang Jili Hospital Changsha China
Abstract
AbstractINTRODUCTIONWhether the integration of eye‐tracking, gait, and corresponding dual‐task analysis can distinguish cognitive impairment (CI) patients from controls remains unclear.METHODSOne thousand four hundred eighty‐one participants, including 724 CI and 757 controls, were enrolled in this study. Eye movement and gait, combined with dual‐task patterns, were measured. The LightGBM machine learning models were constructed.RESULTSA total of 105 gait and eye‐tracking features were extracted. Forty‐six parameters, including 32 gait and 14 eye‐tracking features, showed significant differences between two groups (P < 0.05). Of these, the Gait_3Back‐TurnTime and Dual‐task cost‐TurnTime patterns were significantly correlated with plasma phosphorylated tau 181 (p‐tau181) level. A model based on dual‐task gait, dual‐task smooth pursuit, prosaccade, and anti‐saccade achieved the best area under the receiver operating characteristics curve (AUC) of 0.987 for CI detection, while combined with p‐tau181, the model discriminated mild cognitive impairment from controls with an AUC of 0.824.DISCUSSIONCombining dual‐task gait and dual‐task eye‐tracking analysis is feasible for the detection of CI.Highlights
This is the first study to report the efficiency of integrated parameters of dual‐task gait and eye‐tracking for cognitive impairment (CI) detection in a large cohort.
We identified 46 gait and eye‐tracking features associated with CI, and two were correlated to plasma phosphorylated tau 181.
We constructed the model based on dual‐task gait, smooth pursuit, prosaccade, and anti‐saccade, achieving the best area under the curve of 0.987 for CI detection.
Funder
National Key Research and Development Program of China
National Natural Science Foundation of China
China Postdoctoral Science Foundation
Subject
Psychiatry and Mental health,Cellular and Molecular Neuroscience,Geriatrics and Gerontology,Neurology (clinical),Developmental Neuroscience,Health Policy,Epidemiology