Identifying differential regulatory control of <i>APOE</i> ɛ4 on African versus European haplotypes as potential therapeutic targets-Reference-Cited by-同舟云学术

Identifying differential regulatory control of APOE ɛ4 on African versus European haplotypes as potential therapeutic targets

Published:2022-01-03 Issue:10 Volume:18 Page:1930-1942
ISSN:1552-5260
Container-title:Alzheimer's & Dementia
language:en
Short-container-title:Alzheimer's & Dementia

Author:

Nuytemans Karen¹²^ORCID,Lipkin Vasquez Marina¹,Wang Liyong¹²,Van Booven Derek¹,Griswold Antony J.¹²,Rajabli Farid¹²,Celis Katrina¹,Oron Oded¹,Hofmann Natalia¹,Rolati Sophie¹,Garcia‐Serje Catherine¹,Zhang Shanshan³⁴,Jin Fulai³⁵,Argenziano Mariana⁶,Grant Struan F.A.⁷⁸⁹¹⁰¹¹,Chesi Alessandra⁷⁸¹²,Brown Christopher D.¹³,Young Juan I.¹²,Dykxhoorn Derek M.¹²,Pericak‐Vance Margaret A.¹²,Vance Jeffery M.¹²

Affiliation:

1. John P. Hussman Institute for Human Genomics University of Miami Miller School of Medicine Miami Florida USA

2. John T. Macdonald Foundation Department of Human Genetics University of Miami Miller School of Medicine Miami Florida USA

3. Department of Genetics and Genome Sciences School of Medicine Case Western Reserve University Cleveland Ohio USA

4. The Biomedical Sciences Training Program (BSTP) School of Medicine Case Western Reserve University Cleveland Ohio USA

5. Department of Computer and Data Sciences Case Comprehensive Cancer Center Case Western Reserve University Cleveland Ohio USA

6. Heart Institute University of South Florida Tampa Florida USA

7. Division of Human Genetics Children's Hospital of Philadelphia Philadelphia Pennsylvania USA

8. Department of Genetics University of Pennsylvania Philadelphia Pennsylvania USA

9. Center for Spatial and Functional Genomics Children's Hospital of Philadelphia Philadelphia Pennsylvania USA

10. Division of Endocrinology and Diabetes Children's Hospital of Philadelphia Philadelphia Pennsylvania USA

11. Department of Pediatrics Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA

12. Department of Pathology and Laboratory Medicine University of Pennsylvania Perelman School of Medicine Philadelphia Pennsylvania USA

13. Department of Genetics University of Pennsylvania Perelman School of Medicine Philadelphia Pennsylvania USA

Publisher

Wiley

Subject

Psychiatry and Mental health,Cellular and Molecular Neuroscience,Geriatrics and Gerontology,Neurology (clinical),Developmental Neuroscience,Health Policy,Epidemiology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/alz.12534

Reference48 articles.

1. Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

2. Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease

3. Effects of Age, Sex, and Ethnicity on the Association Between Apolipoprotein E Genotype and Alzheimer Disease

4. Ancestral origin of ApoE ε4 Alzheimer disease risk in Puerto Rican and African American populations

5. Local ancestry at APOE modifies Alzheimer's disease risk in Caribbean Hispanics

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1. Report of the APOE4 National Institute on Aging/Alzheimer Disease Sequencing Project Consortium Working Group: Reducing APOE4 in Carriers is a Therapeutic Goal for Alzheimer's Disease;Annals of Neurology;2024-01-05

2. APOE-Genotype and Insulin Modulate Estimated Effect of Dietary Macronutrients on Cognitive Performance: Panel Analyses in Nondiabetic Older Adults at Risk of Dementia;The Journal of Nutrition;2023-12

3. Transferability of a European-derived Alzheimer’s Disease Genetic Risk Score across Multi-Ancestry Populations;2023-10-19

4. Strengthening Brain Research in Africa;Journal of Alzheimer's Disease Reports;2023-09-07

5. The APOE-TOMM40 Humanized Mouse Model: Characterization of Age, Sex, and PolyT Variant Effects on Gene Expression;Journal of Alzheimer's Disease;2023-08-15