Effect of vigorous‐intensity physical activity on incident cognitive impairment in high‐risk hypertension

Author:

Kazibwe Richard1ORCID,Schaich Christopher L.2,Muhammad Ahmad Imtiaz3,Epiu Isabella4,Namutebi Juliana H.5,Chevli Parag A.1,Kazibwe Joseph6,Hughes Timothy7,Rikhi Rishi R.8,Shapiro Michael D.8,Yeboah Joseph8

Affiliation:

1. Department of Internal Medicine Wake Forest University School of Medicine Winston‐Salem North Carolina USA

2. Hypertension and Vascular Research Center Wake Forest University School of Medicine Winston‐Salem North Carolina USA

3. Department of Medicine Section on Hospital Medicine Wisconsin College of Medicine Milwaukee Wisconsin USA

4. Prince of Wales Clinical School University of New South Wales Sydney Sydney New South Wales Australia

5. Wake Forest University School of Graduate Studies Winston‐Salem North Carolina USA

6. Department of Cardiology Sheffield Teaching Hospital Sheffield UK

7. Department of Medicine Section on Cardiovascular Medicine, Wake Forest University School of Medicine Winston‐Salem North Carolina USA

8. Department of Internal Medicine Section on Gerontology and Geriatrics Medicine & Sticht Center for Healthy Aging and Alzheimer's Prevention Wake Forest University School of Medicine Winston‐Salem North Carolina USA

Abstract

AbstractINTRODUCTIONWe investigated the effect vigorous physical activity (VPA) on the risk of incident mild cognitive impairment (MCI) and probable dementia among individuals with high‐risk hypertension.METHODSBaseline self‐reported frequency of VPA was categorized into low VPA (<1 session/week), and high VPA (≥1 session/week). We used multivariate Cox regression analysis to examine the association of VPA categories with incident MCI and probable dementia events.RESULTSParticipants in the high VPA category, compared with low VPA, experienced lower events rates (per 1000 person‐years) of MCI (13.9 vs 19.7), probable dementia (6.3 vs 9.0), and MCI/probable dementia (18.5 vs 25.8). In the multivariate Cox regression model, high VPA, compared with low VPA, was associated with lower risk of MCI, probable dementia, and MCI/probable dementia (HR [95% CI]: 0.81 [0.68–0.97], 0.80 [0.63–1.03], and 0.82 [0.70–0.96]), respectively.DISCUSSIONThis study provides evidence that VPA may preserve cognitive function in high‐risk patients with hypertension.Highlights Hypertension is associated with an increased risk of cognitive impairment Physical activity (PA) is associated with a lower risk of decline in cognition The effect of ≥1 sessions of vigorous‐intensity PA (VPA) per week was assessed This analysis included SPRINT MIND trial participants with high‐risk hypertension ≥1 VPA sessions/week was associated with lower risk of future cognitive impairment

Funder

National Institutes of Health

National Heart, Lung, and Blood Institute

National Institute of Diabetes and Digestive and Kidney Diseases

National Institute on Aging

National Institute of Neurological Disorders and Stroke

Publisher

Wiley

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