Thrombin down-regulates the TGF-β-mediated synthesis of collagen and fibronectin by human proximal tubule epithelial cells through the EPCR-dependent activation of PAR-1-Reference-Cited by-同舟云学术

Thrombin down-regulates the TGF-β-mediated synthesis of collagen and fibronectin by human proximal tubule epithelial cells through the EPCR-dependent activation of PAR-1

Published:2010-05-19 Issue:1 Volume:225 Page:233-239
ISSN:0021-9541
Container-title:Journal of Cellular Physiology
language:en
Short-container-title:J. Cell. Physiol.

Author:

Bae Jong-Sup,Kim In-San,Rezaie Alireza R.

Publisher

Wiley

Subject

Cell Biology,Clinical Biochemistry,Physiology

Reference49 articles.

1. Protease activated receptor 1 (PAR-1) activation by thrombin is protective in human pulmonary artery endothelial cells if endothelial protein C receptor is occupied by its natural ligand;Bae;Thromb Haemost,2008

2. Thrombin inhibits nuclear factor kappaB and RhoA pathways in cytokine-stimulated vascular endothelial cells when EPCR is occupied by protein C;Bae;Thromb Haemost,2009

3. The ligand occupancy of endothelial protein C receptor switches the protease-activated receptor 1-dependent signaling specificity of thrombin from a permeability-enhancing to a barrier-protective response in endothelial cells;Bae;Blood,2007a

4. Receptors of the protein C activation and activated protein C signaling pathways are colocalized in lipid rafts of endothelial cells;Bae;Proc Natl Acad Sci USA,2007b

5. Concentration dependent dual effect of thrombin in endothelial cells via Par-1 and Pi3 Kinase;Bae;J Cell Physiol,2009

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