Prognostic impact of aberrant right hepatic artery involvement in patients with pancreatic cancer: A multicenter retrospective cohort study

Author:

Ueda Hiroki12ORCID,Takahashi Hidenori12,Akita Hirofumi2,Tomimaru Yoshito1,Kobayashi Shogo1,Kubo Masahiko2,Mukai Yousuke2,Toshiyama Reishi3,Sasaki Kazuki1,Hasegawa Shinichiro2,Iwagami Yoshifumi1,Sakai Kenji3,Yamada Daisaku1ORCID,Noda Takehiro1,Asaoka Tadafumi4,Wada Hiroshi2,Gotoh Kunihito3,Doki Yuichiro1,Eguchi Hidetoshi1ORCID

Affiliation:

1. Department of Gastroenterological Surgery, Graduate School of Medicine Osaka University Suita Osaka Japan

2. Department of Gastroenterological Surgery Osaka International Cancer Institute Osaka Japan

3. Department of Surgery NHO Osaka National Hospital Osaka Japan

4. Department of Gastroenterological Surgery Osaka Police Hospital Osaka Japan

Abstract

AbstractBackground and ObjectivesThis study aimed to evaluate the prognostic value of aberrant right hepatic artery (A‐RHA) involvement in patients with pancreatic cancer (PC).MethodsThis study enrolled 474 patients who underwent upfront pancreatectomy or neoadjuvant treatment for resectable (R) or borderline resectable (BR) PC from four institutions. The patients were divided into three groups: A‐RHA involvement group (n = 12), patients who had sole A‐RHA involvement without major arterial involvement; BR‐A group (n = 104), patients who had major arterial involvement; R/BR‐PV group (n = 358), others.ResultsAll patients in the A‐RHA involvement group underwent margin‐negative resection. The median overall survival of the entire cohort in the A‐RHA involvement, R/BR‐PV, and BR‐A groups was 41.2, 33.5, and 25.2 months, respectively. Although survival in the R/BR‐PV group was significantly more favorable than that in the BR‐A group (p = 0.0003), no significant difference was observed between the A‐RHA involvement group and the R/BR‐PV (p = 0.7332) and BR‐A (p = 0.1485) groups.ConclusionsThe prognosis of patients with PC and sole A‐RHA involvement was comparable to that of patients with R/BR‐PV.

Publisher

Wiley

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