Adiposity and breast, endometrial, and colorectal cancer risk in postmenopausal women: Quantification of the mediating effects of leptin, C‐reactive protein, fasting insulin, and estradiol

Author:

Dashti S. Ghazaleh12ORCID,Simpson Julie A.2,Viallon Vivian3,Karahalios Amalia2,Moreno‐Betancur Margarita14,Brasky Theodore5,Pan Kathy6,Rohan Thomas E.7,Shadyab Aladdin H.8,Thomson Cynthia A.9,Wild Robert A.10,Wassertheil‐Smoller Sylvia7,Ho Gloria Y. F.7,Strickler Howard D.7,English Dallas R.2,Gunter Marc J.3

Affiliation:

1. Clinical Epidemiology and Biostatistics Unit Murdoch Children’s Research Institute Melbourne Australia

2. Centre for Epidemiology and Biostatistics Melbourne School of Population and Global Health The University of Melbourne Melbourne Australia

3. Nutrition and Metabolism Branch International Agency for Research on Cancer (IARC) Lyon France

4. Clinical Epidemiology and Biostatistics Unit Department of Paediatrics University of Melbourne Melbourne Australia

5. The Ohio State University College of Medicine Columbus Ohio USA

6. Hematology/Oncology Kaiser Permanente Downey Downey California USA

7. Department of Epidemiology and Population Health Albert Einstein College of Medicine Bronx New York USA

8. Herbert Wertheim School of Public Health and Human Longevity Science University of California San Diego USA

9. Health Promotion Sciences Mel & Enid Zickerman College of Public Health University of Arizona Cancer Center Tucson Arizona USA

10. Obstetrics and Gynecology, Biostatistics and Epidemiology Oklahoma University Health Sciences Centre Oklahoma City Oklahoma USA

Funder

National Health and Medical Research Council

Breast Cancer Research Foundation

Publisher

Wiley

Subject

Cancer Research,Radiology, Nuclear Medicine and imaging,Oncology

Reference54 articles.

1. Absence of excess body fatness;IARC;IARC Handb Cancer Prev,2018

2. World Cancer Research Fund/American Institute for Cancer Research.Diet Nutrition Physical Activity and Cancer: a Global Perspective. Continuous Update Project Expert Rerpor 2018. Available athttp://dietandcancerreport.org/.

3. The role of leptin in the control of insulin-glucose axis

4. Obesity, Inflammation, and Cancer

5. Hallmarks of Cancer: The Next Generation

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