Studies on Synthesis and Intramolecular Catalyzed Hydrolysis of Thiophosphoramidate Derivatives of Nucleoside

Abstract

AbstractNovel thiophosphoramidate derivatives of nucleoside analogue as membrane‐soluble prodrugs of the bioactive free nucleotides have been prepared by thiophosphorylation reaction. 2′,3′‐O,O′‐Isopropylidene uridine‐5′‐ylN‐thiophosphoryl serine and threonine methyl esters underwent the intramolecular catalyzed hydrolysis reaction.