MutT Homolog 1 Inhibitor Karonudib Attenuates Autoimmune Hepatitis by Inhibiting DNA Repair in Activated T Cells

Author:

Chen Yong1,Hua Xiangwei234,Huang Bingyuan1,Karsten Stella3ORCID,You Zhengrui1,Li Bo1,Li You1,Li Yikang1,Liang Jubo1,Zhang Jun1,Wei Yiran1,Chen Ruiling1,Lyu Zhuwan1ORCID,Xiao Xiao1,Lian Min1,Wei Jue5,Fang Jingyuan1,Miao Qi1,Wang Qixia1,Berglung Ulrika Warpman3,Tang Ruqi1,Helleday Thomas36,Ma Xiong1ORCID

Affiliation:

1. Division of Gastroenterology and Hepatology Key Laboratory of Gastroenterology and Hepatology Ministry of Health State Key Laboratory for Oncogenes and Related Genes Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai Institute of Digestive Disease Shanghai China

2. Department of Thyroid Breast Oncology Shanghai East Hospital, School of Medicine, Tongji University School of Medicine Shanghai China

3. Science for Life Laboratory Department of Oncology and Pathology Karolinska Institutet Stockholm Sweden

4. Department of Liver Surgery and Liver Transplantation Center Renji HospitalSchool of Medicine Shanghai China

5. Department of Gastroenterology Shanghai Tongren HospitalSchool of MedicineShanghai Jiao Tong University Shanghai China

6. Weston Park Cancer Centre Department of Oncology and Metabolism University of Sheffield Sheffield United Kingdom

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Hepatology

Reference42 articles.

1. Diagnosis and treatment of autoimmune hepatitis;Czaja AJ;Hepatology,2002

2. Autoimmune hepatitis;Mieli‐Vergani G;Nat Rev Dis Primers,2018

3. Diagnosis and management of autoimmune hepatitis;Manns MP;Hepatology,2010

4. A system to determine risk of osteoporosis in patients with autoimmune hepatitis;Schmidt T;Clin Gastroenterol Hepatol,2020

5. Therapeutic strategies for autoimmune hepatitis;Manns MP;Dig Dis,2011

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