Outcomes in surgical management of sinonasal malignancy—A single comprehensive cancer center experience

Author:

Adilbay Dauren1ORCID,Valero Cristina1,Fitzgerald Conall1,Yuan Avery1,Mimica Ximena1,Gupta Piyush1,Wong Richard J.1,Shah Jatin P.1ORCID,Patel Snehal G.1,Ganly Ian1ORCID,Cohen Marc A.1ORCID

Affiliation:

1. Department of Surgery, Head and Neck Service Memorial Sloan Kettering Cancer Center New York New York USA

Abstract

AbstractBackgroundSinonasal malignancies are a complex and diverse group of tumors. Over the past five decades, treatment advances have changed the management paradigms for these tumors. Our aim was to analyze the outcomes of patients from a comprehensive cancer center.Materials and MethodsWe retrospectively assessed 400 patients with sinonasal malignancies treated with surgery at our center between 1973 and 2015. Multiple variables were reviewed to assess the influence on 5‐year outcomes.ResultsThe median age was 56 years (IQR 46.8–68). Two hundred and fifty‐nine (65%) were males and 141 (35%) were females. Overall survival (OS) and disease‐specific survival (DSS) improved in the last analyzed decade. Orbital invasion, advanced pT‐classification and pN‐classification, and melanoma histology were associated with poorer outcomes.ConclusionTreatment outcomes for patients with sinonasal malignancy have improved over time. This is likely multifactorial with advances in surgical technique, adjuvant treatment, and patient selection. pT‐classification, pN‐classification, orbital invasion, and histology are predictive of survival.

Funder

National Institutes of Health

Publisher

Wiley

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