The HIV-1 p66 homodimeric RT exhibits different conformations in the binding-competent and -incompetent NNRTI site

Author:

Sharaf Naima G.1,Xi Zhaoyong1,Ishima Rieko1,Gronenborn Angela M.1ORCID

Affiliation:

1. Department of Structural Biology; University of Pittsburgh School of Medicine; Pittsburgh Pennsylvania 15260

Funder

National Institutes of Health

Publisher

Wiley

Subject

Molecular Biology,Biochemistry,Structural Biology

Reference40 articles.

1. The retroviral enzymes;Katz;Annu Rev Biochem.,1994

2. Retroviral reverse transcriptases (other than those of HIV-1 and murine leukemia virus): A comparison of their molecular and biochemical properties;Hizi;Virus Res.,2008

3. Retroviral reverse transcriptases;Herschhorn;Cell Mol Life Sci.,2010

4. Purification and characterization of heterodimeric human immunodeficiency virus type 1 (HIV-1) reverse transcriptase produced by in vitro processing of p66 with recombinant HIV-1 protease;Chattopadhyay;J Biol Chem.,1992

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