The regulatory roles and clinical significance of glycolysis in tumor

Author:

Qiao Qiqi1,Hu Shunfeng12,Wang Xin12345ORCID

Affiliation:

1. Department of Hematology Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan Shandong P. R. China

2. Department of Hematology Shandong Provincial Hospital Shandong University Jinan Shandong P. R. China

3. Taishan Scholars Program of Shandong Province Jinan Shandong P. R. China

4. Branch of National Clinical Research Center for Hematologic Diseases Jinan Shandong P. R. China

5. National Clinical Research Center for Hematologic Diseases the First Affiliated Hospital of Soochow University Suzhou Jiangsu P. R. China

Abstract

AbstractMetabolic reprogramming has been demonstrated to have a significant impact on the biological behaviors of tumor cells, among which glycolysis is an important form. Recent research has revealed that the heightened glycolysis levels, the abnormal expression of glycolytic enzymes, and the accumulation of glycolytic products could regulate the growth, proliferation, invasion, and metastasis of tumor cells and provide a favorable microenvironment for tumor development and progression. Based on the distinctive glycolytic characteristics of tumor cells, novel imaging tests have been developed to evaluate tumor proliferation and metastasis. In addition, glycolytic enzymes have been found to serve as promising biomarkers in tumor, which could provide assistance in the early diagnosis and prognostic assessment of tumor patients. Numerous glycolytic enzymes have been identified as potential therapeutic targets for tumor treatment, and various small molecule inhibitors targeting glycolytic enzymes have been developed to inhibit tumor development and some of them are already applied in the clinic. In this review, we systematically summarized recent advances of the regulatory roles of glycolysis in tumor progression and highlighted the potential clinical significance of glycolytic enzymes and products as novel biomarkers and therapeutic targets in tumor treatment.

Funder

Natural Science Foundation of Shandong Province

Key Technology Research and Development Program of Shandong Province

China Postdoctoral Science Foundation

Publisher

Wiley

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