Affiliation:
1. MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou 310058 China
2. Shanghai Key Laboratory of Advanced Polymeric Materials School of Materials Science and Engineering East China University of Science and Technology Shanghai 200237 China
3. Department of Radiology Sir Run Run Shaw Hospital School of Medicine Zhejiang University Hangzhou 310016 China
Abstract
AbstractHyperbranched poly(α‐amino acid)s have caught great attention due to their excellent biocompatibility, biodegradability, and bioactivity. However, hyperbranched polypeptoids are rarely reported because of the challenge of synthesis. Herein, unique polymerizations of N,N'‐diphenoxycarbonyl‐N,N'‐(1,4‐phenylenebismethylene)–diglycine (di‐NNPC, an A*B*‐A*B*‐type monomer) which uncommonly result in hyperbranched polypeptoids rather than gels after the complete consumption of di‐NNPC are reported. The molecular weights of the hyperbranched polypeptoids are controlled by the degree of branching via tuning the initial concentrations of monomer and basic catalyst. N‐Phenyloxycarbonyl glycine pendant groups plentifully remained on the polymer chains are used for Gd3+ complexation and post‐modification, which makes the hyperbranched polypeptoids multifunctional single molecular micelles applicable as magnetic resonance imaging contrast agents and photoluminescence probes.
Funder
National Natural Science Foundation of China
Subject
Materials Chemistry,Organic Chemistry,Polymers and Plastics,Physical and Theoretical Chemistry,Condensed Matter Physics
Cited by
1 articles.
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