What we learn about bipolar disorder from large‐scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group

Author:

Ching Christopher R. K.1ORCID,Hibar Derrek P.2,Gurholt Tiril P.34ORCID,Nunes Abraham56,Thomopoulos Sophia I.1,Abé Christoph67,Agartz Ingrid389,Brouwer Rachel M.10,Cannon Dara M.11,Zwarte Sonja M. C.10,Eyler Lisa T.1213,Favre Pauline1415,Hajek Tomas416ORCID,Haukvik Unn K.417ORCID,Houenou Josselin141518,Landén Mikael1920,Lett Tristram A.2122,McDonald Colm10,Nabulsi Leila110,Patel Yash23,Pauling Melissa E.1314,Paus Tomas2324,Radua Joaquim8252627,Soeiro‐de‐Souza Marcio G.28,Tronchin Giulia10,Haren Neeltje E. M.29,Vieta Eduard2530,Walter Henrik21,Zeng Ling‐Li131,Alda Martin4,Almeida Jorge32,Alnæs Dag3,Alonso‐Lana Silvia3334,Altimus Cara35,Bauer Michael36,Baune Bernhard T.373839,Bearden Carrie E.4041ORCID,Bellani Marcella42,Benedetti Francesco4344,Berk Michael4546,Bilderbeck Amy C.4748,Blumberg Hilary P.49,Bøen Erlend50,Bollettini Irene44,Mar Bonnin Caterina2530,Brambilla Paolo5152,Canales‐Rodríguez Erick J.33345354,Caseras Xavier55,Dandash Orwa5657,Dannlowski Udo37,Delvecchio Giuseppe51,Díaz‐Zuluaga Ana M.58,Dima Danai5960,Duchesnay Édouard14,Elvsåshagen Torbjørn176162,Fears Scott C.6364,Frangou Sophia6566,Fullerton Janice M.6768,Glahn David C.69ORCID,Goikolea Jose M.2530,Green Melissa J.6770,Grotegerd Dominik37,Gruber Oliver71,Haarman Bartholomeus C. M.72ORCID,Henry Chantal7374,Howells Fleur M.7576ORCID,Ives‐Deliperi Victoria75,Jansen Andreas7778,Kircher Tilo T. J.78,Knöchel Christian79,Kramer Bernd71,Lafer Beny80,López‐Jaramillo Carlos5881,Machado‐Vieira Rodrigo82,MacIntosh Bradley J.8384ORCID,Melloni Elisa M. T.4344,Mitchell Philip B.70,Nenadic Igor78,Nery Fabiano8586,Nugent Allison C.87,Oertel Viola79,Ophoff Roel A.8889,Ota Miho90,Overs Bronwyn J.67,Pham Daniel L.35,Phillips Mary L.91,Pineda‐Zapata Julian A.92,Poletti Sara4344,Polosan Mircea9394,Pomarol‐Clotet Edith3334,Pouchon Arnaud93,Quidé Yann6770ORCID,Rive Maria M.95,Roberts Gloria70,Ruhe Henricus G.9697,Salvador Raymond3334,Sarró Salvador3334,Satterthwaite Theodore D.98,Schene Aart H.96,Sim Kang99100,Soares Jair C.101102,Stäblein Michael79,Stein Dan J.7576103,Tamnes Christian K.38104,Thomaidis Georgios V.105106,Upegui Cristian Vargas58ORCID,Veltman Dick J.107,Wessa Michèle108,Westlye Lars T.109110,Whalley Heather C.111,Wolf Daniel H.98,Wu Mon‐Ju102,Yatham Lakshmi N.112,Zarate Carlos A.113114,Thompson Paul M.1,Andreassen Ole A.34,

Affiliation:

1. Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine University of Southern California Los Angeles California USA

2. Genentech, Inc. South San Francisco California USA

3. Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo Oslo Norway

4. Division of Mental Health and Addicition, Oslo University Hospital Oslo Norway

5. Department of Psychiatry Dalhousie University Halifax Nova Scotia Canada

6. Faculty of Computer Science Dalhousie University Halifax Nova Scotia Canada

7. Department of Clinical Neuroscience Karolinska Institutet Stockholm Sweden

8. Department of Psychiatric Research Diakonhjemmet Hospital Oslo Norway

9. Center for Psychiatric Research, Department of Clinical Neuroscience Karolinska Institutet Stockholm Sweden

10. Department of Psychiatry, University Medical Center Utrecht Brain Center, University Medical Center Utrecht Utrecht University Utrecht The Netherlands

11. Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences National University of Ireland Galway Galway Ireland

12. Department of Psychiatry University of California La Jolla California USA

13. Desert‐Pacific MIRECC VA San Diego Healthcare San Diego California USA

14. INSERM U955, team 15 “Translational Neuro‐Psychiatry” Créteil France

15. Neurospin, CEA Paris‐Saclay, team UNIACT Gif‐sur‐Yvette France

16. National Institute of Mental Health Klecany Czech Republic

17. Norwegian Centre for Mental Disorders Research (NORMENT) Oslo University Hospital Oslo Norway

18. APHP Mondor University Hospitals, DMU IMPACT Créteil France

19. Department of Neuroscience and Physiology University of Gothenburg Gothenburg Sweden

20. Department of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm Sweden

21. Department for Psychiatry and Psychotherapy Charité Universitätsmedizin Berlin Berlin Germany

22. Department of Neurology with Experimental Neurology Charité Universitätsmedizin Berlin Berlin Germany

23. Bloorview Research Institute Holland Bloorview Kids Rehabilitation Hospital Toronto Ontario Canada

24. Departments of Psychology and Psychiatry University of Toronto Toronto Ontario Canada

25. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM) Barcelona Spain

26. Early Psychosis: Interventions and Clinical‐detection (EPIC) lab, Department of Psychosis Studies Institute of Psychiatry, Psychology and Neuroscience, King's College London London UK

27. Stockholm Health Care Services Stockholm County Council Stockholm Sweden

28. Mood Disorders Unit (GRUDA), Hospital das Clinicas HCFMUSP, Faculdade de Medicina Universidade de São Paulo São Paulo SP Brazil

29. Department of Child and Adolescent Psychiatry/Psychology Erasmus Medical Center Rotterdam The Netherlands

30. Barcelona Bipolar Disorders and Depressive Unit, Hospital Clinic, Institute of Neurosciences University of Barcelona Barcelona Spain

31. College of Intelligence Science and Technology National University of Defense Technology Changsha China

32. Dell Medical School The University of Texas at Austin Austin Texas USA

33. FIDMAG Germanes Hospitalàries Research Foundation Barcelona Spain

34. CIBERSAM Madrid Spain

35. Milken Institute Center for Strategic Philanthropy Washington District of Columbia USA

36. Department of Psychiatry and Psychotherapy, Medical Faculty Technische Universität Dresden Dresden Germany

37. Department of Psychiatry University of Münster Münster Germany

38. Department of Psychiatry The University of Melbourne Melbourne Victoria Australia

39. The Florey Institute of Neuroscience and Mental Health The University of Melbourne Melbourne Victoria Australia

40. Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior University of California Los Angeles California USA

41. Department of Psychology University of California Los Angeles California USA

42. Section of Psychiatry, Department of Neurosciences, Biomedicine and Movement Sciences University of Verona Verona Italy

43. Vita‐Salute San Raffaele University Milan Italy

44. Division of Neuroscience, Psychiatry and Psychobiology Unit IRCCS San Raffaele Scientific Institute Milan Italy

45. Department of Pathophysiology and Transplantation University of Milan Milan Italy

46. IMPACT Institute – The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health Deakin University Geelong Victoria Australia

47. The National Centre of Excellence in Youth Mental Health, Centre for Youth Mental Health, Florey Institute for Neuroscience and Mental Health and the Department of Psychiatry, The University of Melbourne Orygen Melbourne Victoria Australia

48. P1vital Ltd Wallingford UK

49. Department of Psychiatry University of Oxford Oxford UK

50. Mood Disorders Research Program Yale School of Medicine New Haven Connecticut USA

51. Psychosomatic and CL Psychiatry Oslo University Hospital Oslo Norway

52. Department of Neurosciences and Mental Health Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milan Italy

53. Department of Radiology Centre Hospitalier Universitaire Vaudois (CHUV) Lausanne Switzerland

54. Signal Processing Lab (LTS5), École Polytechnique Fédérale de Lausanne Lausanne Switzerland

55. MRC Centre for Neuropsychiatric Genetics and Genomics Cardiff University Cardiff UK

56. Melbourne Neuropsychiatry Centre, Department of Psychiatry University of Melbourne and Melbourne Health Melbourne Victoria Australia

57. Brain, Mind and Society Research Hub, Turner Institute for Brain and Mental Health, School of Psychological Sciences Monash University Clayton Victoria Australia

58. Research Group in Psychiatry GIPSI, Department of Psychiatry Faculty of Medicine, Universidad de Antioquia Medellín Colombia

59. Department of Psychology, School of Social Sciences and Arts City, University of London London UK

60. Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience King's College London London UK

61. Department of Neurology Oslo University Hospital Oslo Norway

62. Institute of Clinical Medicine University of Oslo Oslo Norway

63. Center for Neurobehavioral Genetics Los Angeles California USA

64. Greater Los Angeles Veterans Administration Los Angeles California USA

65. Centre for Brain Health University of British Columbia Vancouver British Columbia Canada

66. Department of Psychiatry Icahn School of Medicine at Mount Sinai New York New York USA

67. Neuroscience Research Australia Randwick New South Wales Australia

68. School of Medical Sciences University of New South Wales Sydney New South Wales Australia

69. Department of Psychiatry Boston Children's Hospital and Harvard Medical School Boston Massachusetts USA

70. School of Psychiatry University of New South Wales Sydney New South Wales Australia

71. Department of General Psychiatry Heidelberg University Heidelberg Germany

72. Department of Psychiatry, University Medical Center Groningen University of Groningen Groningen The Netherlands

73. Department of Psychiatry Service Hospitalo‐Universitaire, GHU Paris Psychiatrie & Neurosciences Paris France

74. Université de Paris Paris France

75. Neuroscience Institute University of Cape Town Cape Town South Africa

76. Department of Psychiatry and Mental Health University of Cape Town Cape Town South Africa

77. Core‐Facility Brainimaging, Faculty of Medicine University of Marburg Marburg Germany

78. Department of Psychiatry and Psychotherapy Philipps‐University Marburg Marburg Germany

79. Department of Psychiatry, Psychosomatic Medicine and Psychotherapy Goethe University Frankfurt Frankfurt Germany

80. Laboratory of Psychiatric Neuroimaging (LIM‐21), Departamento e Instituto de Psiquiatria Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo São Paulo SP Brazil

81. Mood Disorders Program Hospital Universitario Trastorno del Ánimo Medellín Colombia

82. Experimental Therapeutics and Molecular Pathophysiology Program, Department of Psychiatry UTHealth, University of Texas Houston Texas USA

83. Hurvitz Brain Sciences Sunnybrook Research Institute Toronto Ontario Canada

84. Department of Medical Biophysics University of Toronto Toronto Ontario Canada

85. University of Cincinnati Cincinnati Ohio USA

86. Universidade de São Paulo São Paulo SP Brazil

87. MEG Core Facility Bethesda Maryland USA

88. UCLA Center for Neurobehavioral Genetics Los Angeles California USA

89. Department of Psychiatry Erasmus Medical Center, Erasmus University Rotterdam The Netherlands

90. Department of Mental Disorder Research National Institute of Neuroscience, National Center of Neurology and Psychiatry Tokyo Japan

91. Department of Psychiatry University of Pittsburgh Pittsburgh Pennsylvania USA

92. Research Group Instituto de Alta Tecnología Médica (IATM) Medellín Colombia

93. University of Grenoble Alpes CHU Grenoble Alpes Grenoble France

94. INSERM U1216 ‐ Grenoble Institut des Neurosciences La Tronche France

95. Department of Psychiatry Amsterdam UMC, location AMC Amsterdam The Netherlands

96. Department of Psychiatry Radboud University Medical Center Nijmegen The Netherlands

97. Donders Institute for Brain, Cognition and Behavior Radboud University Nijmegen The Netherlands

98. Department of Psychiatry University of Pennsylvania Perelman School of Medicine Philadelphia Pennsylvania USA

99. West Region, Institute of Mental Health Singapore Singapore

100. Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore

101. Center of Excellent on Mood Disorders UTHealth Houston Houston Texas USA

102. Department of Psychiatry and Behavioral Sciences UTHealth Houston Houston Texas USA

103. SAMRC Unit on Risk & Resilience in Mental Disorders University of Cape Town Cape Town South Africa

104. PROMENTA Research Center, Department of Psychology University of Oslo Oslo Norway

105. Papanikolaou General Hospital Thessaloniki Greece

106. Laboratory of Mechanics and Materials School of Engineering, Aristotle University Thessaloniki Greece

107. Department of Psychiatry Amsterdam UMC Amsterdam The Netherlands

108. Department of Neuropsychology and Clinical Psychology Johannes Gutenberg‐University Mainz Mainz Germany

109. Department of Psychology University of Oslo Oslo Norway

110. Norwegian Centre for Mental Disorders Research (NORMENT), Department of Mental Health and Addiction Oslo University Hospital Oslo Norway

111. Centre for Clinical Brain Sciences University of Edinburgh Edinburgh UK

112. Department of Psychiatry University of British Columbia Vancouver British Columbia Canada

113. Chief Experimental Therapeutics & Pathophysiology Branch Bethesda Maryland USA

114. Intramural Research Program National Institute of Mental Health Bethesda Maryland USA

Publisher

Wiley

Subject

Neurology (clinical),Neurology,Radiology, Nuclear Medicine and imaging,Radiological and Ultrasound Technology,Anatomy

Reference138 articles.

1. Manic episodes are related to changes in frontal cortex: a longitudinal neuroimaging study of bipolar disorder 1

2. The association of antipsychotic medication and lithium with brain measures in patients with bipolar disorder

3. Novel genetic loci underlying human intracranial volume identified through genome-wide association

4. Altimus C.(2019) Supporting wellness: A survey of lived experience. [PDF file]. Retrieved from:http://milkeninstitute.org/sites/default/files/reports-pdf/Supporting%20Wellness%20-%20Survey%20of%20Lived%20Experience%20with%20Depression%20and%20Bipolar%20Updated.pdf

5. An MRI study of temporal lobe structures in men with bipolar disorder or schizophrenia

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