1. Department of Colorectal Surgery and Oncology Key Laboratory of Cancer Prevention and Intervention Ministry of Education The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang 310009 P. R. China
2. Department of Pharmacology and Department of Gastroenterology of the Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang 310058 P. R. China
3. Department of Cell Biology School of Basic Medical Sciences Zhejiang University Hangzhou Zhejiang 310058 P. R. China
4. Cancer Center Zhejiang University Hangzhou Zhejiang 310058 P. R. China
5. Department of Medical Oncology the Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou Zhejiang 310058 P. R. China