Investigating endocrine‐disrupting properties of chemicals in fish and amphibians: Opportunities to apply the 3Rs

Author:

Burden Natalie1,Embry Michelle R.2,Hutchinson Thomas H.3,Lynn Scott G.4,Maynard Samuel K.5,Mitchell Constance A.2,Pellizzato Francesca6,Sewell Fiona1,Thorpe Karen L.7,Weltje Lennart8ORCID,Wheeler James R.9

Affiliation:

1. NC3Rs London UK

2. Health and Environmental Sciences Institute (HESI) Washington DC USA

3. School of Geography, Earth & Environmental Sciences University of Plymouth Plymouth UK

4. US Environmental Protection Agency (EPA) Office of Science Coordination and Policy Washington DC USA

5. AstraZeneca, Global Sustainability Cambridge UK

6. Hazard Assessment European Chemicals Agency (ECHA) Helsinki Finland

7. Centre for Chemical Safety and Stewardship Fera Science Ltd. York UK

8. BASF SE, Agricultural Solutions−Ecotoxicology Limburgerhof Germany

9. Shell Health, Shell International B.V. The Hague The Netherlands

Funder

National Centre for the Replacement Refinement and Reduction of Animals in Research

Publisher

Wiley

Subject

General Environmental Science,General Medicine,Geography, Planning and Development

Reference46 articles.

1. A novel framework for interpretation of data from the fish short-term reproduction assay (FSTRA) for the detection of endocrine-disrupting chemicals

2. An exposure:activity profiling method for interpreting high-throughput screening data for estrogenic activity—Proof of concept

3. Bonnell M. Inglis C. Jagla M. Prindiville C. J. &Shore B.(2018). Acomputational approach for the ecological prioritization of organic chemicals in Canada: ERC 2.0. Society of Environmental Toxicology and Chemistry 39th Annual Meeting Sacramento CA USA.

4. Bonnell M. Inglis C. Jagla M. Prindiville C. J. &Shore B.(2019).Development of version 2.0 of the ecological risk classification approach for prioritizing organic chemicals. Society of Environmental Toxicology and Chemistry Europe 29th Annual Meeting Helsinki Finland.

5. Historical control data for the interpretation of ecotoxicity data: are we missing a trick?

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