Non‐Pharmacological Interventions in the Management of Dementia‐Related Psychosis: A Systematic Review and Meta‐Analysis

Author:

Burnand Alice1ORCID,Rookes Tasmin1,Mahmood Farah1,Davies Nathan1ORCID,Walters Kate1,Orleans‐Foli Stephen2,Sajid Madiha3,Vickerstaff Victoria4,Frost Rachael15

Affiliation:

1. Centre for Ageing Population Studies Research Department of Primary Care and Population Health University College London London UK

2. Cognitive Impairment and Dementia Services (CIDS) West London NHS Trust Southall UK

3. Patient and Public Involvement Member

4. Research Department of Primary Care and Population Health PRIMENT Clinical Trials Unit University College London London UK

5. School of Public and Allied Health Liverpool John Moores University Liverpool UK

Abstract

ABSTRACTObjectiveAs populations age globally, there is an increasing prevalence of dementia, with an estimated 153 million living with dementia by 2050. Up to 70% of people with dementia experience dementia‐related psychosis (D‐RP). Antipsychotic medications are associated with many adverse effects in older people. This review aims to evaluate the evidence of non‐pharmacological interventions in managing D‐RP.MethodThe search of Medline, EMBASE, Web of Science, CINAHL, PsycINFO, and Cochrane included randomised controlled trials that evaluated non‐pharmacological interventions. Data extraction and assessment of quality were assessed independently by two researchers. Heterogenous interventions were pooled using meta‐analysis.ResultsA total of 18 articles (n = 2040 participants) were included and categorised into: sensory‐, activity‐, cognitive‐ and multi‐component‐orientated. Meta‐analyses showed no significant impact in reducing hallucinations or delusions but person‐centred care, cognitive rehabilitation, music therapy, and robot pets showed promise in single studies.Conclusions and ImplicationsFuture interventions should be developed and evaluated with a specific focus on D‐RP as this was not the aim for many of the included articles.

Funder

NIHR School for Primary Care Research

Publisher

Wiley

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