Intelligent In situ Printing of Multimaterial Bioinks for First‐Aid Wound Care Guided by Eye‐In‐Hand Robot Technology

Author:

Jeong Seol‐Ha1,Kim Jihyun12,Thibault Brendan Craig13,Soto Javier Alejandro Lozano1,Tourk Fatima14,Steakelum Joshua13,Azuela Diego1,Carvalho Violeta15678,Quiroga‐Ocaña Guillermo1,Zhuang Weida1,Cham‐Pérez Mei Li L.19,Huang Lucia L.10,Li Zhuqing11,Valsami Eleftheria‐Angeliki11,Wang Enya11,Rodrigues Nelson5612,Teixeira Senhorinha F.C.F.6,Lee Yuhan10,Seo Jungmok2,Veves Aristidis11,Hassan Shabir1131415,Theocharidis Georgios11,Fiondella Lance3,Shin Su Ryon1ORCID

Affiliation:

1. Division of Engineering in Medicine Department of Medicine Brigham and Women's Hospital Harvard Medical School Boston MA 02139 USA

2. School of Electrical and Electronic Engineering Yonsei University Seoul 03722 Republic of Korea

3. Department of Electrical and Computer Engineering University of Massachusetts Dartmouth North Dartmouth MA 02747 USA

4. Department of Mechanical Engineering Northeastern University Boston MA 02115 USA

5. MEtRICs Mechanical Engineering Department University of Minho Campus de Azurém Guimarães 4800‐058 Portugal

6. ALGORITMI/LASI Center University of Minho Campus de Azurém Guimarães 4800‐058 Portugal

7. Center for MicroElectromechanical Systems (CMEMS‐UMinho) University of Minho Campus de Azurém Guimarães 4800‐058 Portugal

8. LABBELS—Associate Laboratory Braga/Guimarães 4800‐058 Portugal

9. Tecnológico de Monterrey Escuela de Ingeniería y Ciencias Campus Monterrey Av. Eugenio Garza Sada 2501, Col. Tecnológico C.P. Monterrey Nuevo León 64700 Mexico

10. Department of Anesthesiology Perioperative and Pain Medicine, Center for Accelerated Medical Innovation & Center for Nanomedicine Brigham and Women's Hospital Harvard Medical School Boston MA 02115 USA

11. Joslin‐Beth Israel Deaconess Foot Center and The Rongxiang Xu MD Center for Regenerative Therapeutics Beth Israel Deaconess Medical Center Harvard Medical School Boston MA 02215 USA

12. COMEGI – Center for Research in Organizations Markets and Industrial Management Lusíada University Vila Nova de Famalicão 4760‐108 Portugal

13. Department of Biological Sciences Khalifa University Main Campus Abu Dhabi 127788 UAE

14. Center for Biotechnology Khalifa University Main Campus Abu Dhabi 127788 UAE

15. Functional Biomaterials Group Khalifa University SAN Campus Abu Dhabi 127788 UAE

Abstract

AbstractINSIGHT (INtelligent in situ printing Guided by Eye‐in‐Hand robot Technology), an innovative computer vision‐enabled system that combines a depth camera with a 6‐degree of freedom robot arm, empowering it to identify arbitrary areas at various angles through real time adjustments and to enable volumetric printing performed by dynamic image recognition based on color and contour differences is presented. Continuous targeting of multiple wounds at different locations is achieved. The optimized pneumatic valve synchronized with the INSIGHT can print multiple inks with diverse rheological properties to fabricate scaffolds and bandages with the capacity to treat various types of wounds. The design of dual printed modes, such as extrusion and spray, can significantly decrease printing time for large‐scale wounds on an ex vivo porcine model. INSIGHT demonstrates its ability to treat diabetic wounds, using a microgel‐based ink possessing an inherent porous microstructure to facilitate cell infiltration. In vivo verification highlights its adaptability to enable customized care for rapid emergency treatment of trauma patients.

Funder

National Institutes of Health

Korea Health Industry Development Institute

Publisher

Wiley

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