Left‐sided epileptiform activity influences language lateralization in right mesial temporal sclerosis

Author:

de Almeida Juliana Passos12,Castro Bettina Martins12,Passarelli Valmir1,Chaim Khallil Taverna2,Castro‐Lima Humberto13ORCID,Listik Clarice1,Jorge Carmen Lisa1,Valerio Rosa1,Arantes Paula Ricci2,Amaro Edson2,Pipek Leonardo Zumerkorn1ORCID,Castro Luiz H.1ORCID

Affiliation:

1. Department of Neurology, Epilepsy Program, Clinical Hospital University of Sao Paulo School of Medicine Sao Paulo Brazil

2. LIM‐44, Department of Radiology, Faculty of Medicine University of São Paulo Sao Paulo Brazil

3. Bahiana School of Medicine and Public Health Salvador Brazil

Abstract

AbstractObjectiveTo investigate the association between left epileptiform activity and language laterality indices (LI) in patients with right mesial temporal sclerosis (MTS).MethodsTwenty‐two patients with right MTS and 22 healthy subjects underwent fMRI scanning while performing a language task. LI was calculated in multiple regions of interest (ROI). Data on the presence of left epileptiform abnormalities were obtained during prolonged video‐EEG monitoring.ResultsAfter correction for multiple comparisons, LI was reduced in the middle temporal gyrus in the left interictal epileptiform discharges (IED+) group, compared with the left IED− group (p < 0.05).SignificanceUsing a responsive reading naming fMRI paradigm, right MTS patients who presented left temporal interictal epileptiform abnormalities on video‐EEG showed decreased LI in the middle temporal gyrus, indicating decreased left middle temporal gyrus activation, increased right middle temporal gyrus activation or a combination of both, demonstrative of language network reorganization, specially in the MTG, in this patient population.Plain Language SummaryThis research studied 22 patients with right mesial temporal sclerosis (a specific type of epilepsy) comparing them to 22 healthy individuals. Participants were asked to perform a language task while undergoing a special brain imaging technique (fMRI). The findings showed that patients with epilepsy displayed a change in the area of the brain typically responsible for language processing. This suggests that their brains may have adapted due to their condition, altering the way language is processed.

Funder

Fundação de Amparo à Pesquisa do Estado de São Paulo

Publisher

Wiley

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