High‐Throughput Fabrication of Size‐Controlled Pickering Emulsions, Colloidosomes, and Air‐Coated Particles via Clog‐Free Jetting of Suspensions

Author:

Jiang Jieke1ORCID,Poortinga Albert T.2,Liao Yuanyuan3,Kamperman Tom4,Venner Cornelis H.1,Visser Claas Willem1ORCID

Affiliation:

1. Engineering Fluid Dynamics group Department of Thermal and Fluid Engineering Faculty of Engineering Technology University of Twente Enschede 7522 NB Netherlands

2. Polymer Technology Eindhoven University of Technology Eindhoven 5612 AZ Netherlands

3. IamFluidics B.V.  High Tech Factory Enschede 7522 NM Netherlands

4. Department of Developmental BioEngineering Faculty of Science and Technology Technical Medical Centre University of Twente Enschede 7522 NB Netherlands

Abstract

AbstractMicrocapsules with a liquid core and a solid shell composed of hydrophobic nanoparticles are broadly applied in food, pharmaceutics, and biotechnologies. For example, Pickering emulsions, colloidosomes, or antibubbles (droplets surrounded by air layers in water) enable controlled release of active agents, biocompatibility, and contact‐less liquid transportation. However, producing controlled nanoparticle‐ or polymer‐laden hydrophobic shells at scale is highly challenging, since bulk methods are polydisperse and microfluidic chips are prone to clogging and slow. Here, clog‐free coating of an aqueous jet with silica nanoparticle suspensions with concentrations up to 10% (w/v), as well as high concentrations of polymers (30% (w/v) poly(lactic acid) (PLA)), is demonstrated, enabling continuous generation of microcapsules at flow rates up to 4 mL min−1. Pickering emulsions are converted into capsules, providing hydrophobic shells consisting of nanoparticles for controlled release. As a highlight, the scalable fabrication of air‐coated capsules (antibubbles) in the sub‐millimeter range is demonstrated. The shell contains an air film that protects the liquid core for days yet enables ultrasound‐induced release within 3 min. By enabling rapid fabrication of controlled Pickering emulsions, colloidosomes, antibubbles, and biodegradable capsules, jetting through a liquid layer (JetALL) provides a versatile platform for advanced applications in food, pharmacy, and life science.

Funder

European Regional Development Fund

Publisher

Wiley

Subject

Mechanical Engineering,Mechanics of Materials,General Materials Science

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