Affiliation:
1. Department of Biomedical Engineering City University of Hong Kong 83 Tat Chee Avenue Kowloon Hong Kong SAR China
2. Karolinska Institutet Ming Wai Lau Centre for Reparative Medicine HKSTP Sha Tin Hong Kong SAR China
3. School of Chemistry and Chemical Engineering Yangzhou University Yangzhou 225009 P. R. China
4. Shenzhen Research Institute City University of Hong Kong Shenzhen 518057 P. R. China
Abstract
AbstractCatechins from green tea are one of the most effective natural compounds for cancer chemoprevention and have attracted extensive research. Cancer cell‐selective apoptosis‐inducing properties of catechins depend on efficient intracellular delivery. However, the low bioavailability limits the application of catechins. Herein, a nano‐scaled micellar composite composed of catechin‐functionalized cationic lipopolymer and serum albumin is constructed. Cationic liposomes tend to accumulate in the pulmonary microvasculature due to electrostatic effects and are able to deliver the micellar system intracellularly, thus improving the bioavailability of catechins. Albumin in the system acts as a biocompatible anti‐plasma absorbent, forming complexes with positively charged lipopolymer under electrostatic interactions, contributing to prolonged in vivo retention. The physicochemical properties of the nano‐micellar complexes are characterized, and the antitumor properties of catechin‐functionalized materials are confirmed by reactive oxygen species (ROS), caspase‐3, and cell apoptosis measurements. The role of each functional module, cationic polymeric liposome, and albumin is revealed by cell penetration, in vivo animal assays, etc. This multicomponent micellar nanocomposite has the potential to become an effective vehicle for the treatment of lung diseases such as pneumonia, lung tumors, sepsis‐induced lung injury, etc. This study also demonstrates that it is a great strategy to create a delivery system that is both tissue‐targeted and biologically active by combining cationic liposomes with the native bioactive compound catechins.
Funder
National Natural Science Foundation of China
City University of Hong Kong
Subject
Mechanical Engineering,Mechanics of Materials,General Materials Science
Cited by
3 articles.
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