Affiliation:
1. Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM) Nanjing Tech University (NanjingTech) Nanjing 211800 China
2. College of Biotechnology and Bioengineering Zhejiang University of Technology Hangzhou 310032 China
3. Frontiers Science Center for Flexible Electronics Xi'an Institute of Flexible Electronics (IFE) and Xi'an Institute of Biomedical Materials & Engineering Northwestern Polytechnical University Xi'an 710072 China
4. The Institute of Flexible Electronics (IFE, Future Technologies) Xiamen University Xiamen Fujian 361005 China
Abstract
AbstractOrganic phototheranostics simultaneously having fluorescence in the second near‐infrared (NIR‐II, 1000−1700 nm) window, photothermal, and photodynamic functions possess great prospects in tumor diagnosis and therapy. However, such phototheranostics generally suffer from low brightness and poor photodynamic performance due to severe solvatochromism. Herein, an organic NIR‐II fluorophore AS1, which possesses an inverted dependence of fluorescence quantum yield on polarity, is reported to serve as potent phototheranostics for tumor diagnosis and therapy. After encapsulation of AS1 into nanostructures, the obtained phototheranostics (AS1R) exhibit high extinction coefficients (e.g., 68200 L mol−1 cm−1 at 808 nm), NIR‐II emission with high fluorescence quantum yield up to 4.7% beyond 1000 nm, photothermal conversion efficiency of ca. 65%, and 1O2 quantum yield up to 4.1%. The characterization of photophysical properties demonstrates that AS1R are superior to other types of organic phototheranostics in brightness, photothermal effect, and photodynamic performance at the same mass concentration. The excellent phototheranostic performance of AS1R enables clear visualization and complete elimination of tumors using a single and low injection dose. This study demonstrates for the first time the merits and prospects of NIR‐II fluorophore with inverted polarity dependence of fluorescence quantum yield as high‐performance phototheranostic agents for fluorescence imaging and phototherapy of tumors.This article is protected by copyright. All rights reserved
Subject
Mechanical Engineering,Mechanics of Materials,General Materials Science
Cited by
3 articles.
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