Leveraging Semiconducting Polymer Nanoparticles for Combination Cancer Immunotherapy

Author:

Wu Jiayan1,Pu Kanyi12ORCID

Affiliation:

1. School of Chemistry, Chemical Engineering and Biotechnology Nanyang Technological University 70 Nanyang Drive Singapore 637457 Singapore

2. Lee Kong Chian School of Medicine Nanyang Technological University 59 Nanyang Drive Singapore 636921 Singapore

Abstract

AbstractCancer immunotherapy has become a promising method for cancer treatment, bringing hope to advanced cancer patients. However, immune‐related adverse events caused by immunotherapy also bring heavy burden to patients. Semiconducting polymer nanoparticles (SPNs) as an emerging nanomaterial with high biocompatibility, can eliminate tumors and induce tumor immunogenic cell death through different therapeutic modalities, including photothermal therapy, photodynamic therapy, and sonodynamic therapy. In addition, SPNs can work as a functional nanocarrier to synergize with a variety of immunomodulators to amplify anti‐tumor immune responses. In this review, SPNs‐based combination cancer immunotherapy is comprehensively summarized according to the SPNs’ therapeutic modalities and the type of loaded immunomodulators. The in‐depth understanding of existing SPNs‐based therapeutic modalities will hopefully inspire the design of more novel nanomaterials with potent anti‐tumor immune effects, and ultimately promote their clinical translation.

Funder

National Research Foundation Singapore

Agency for Science, Technology and Research

Publisher

Wiley

Subject

Mechanical Engineering,Mechanics of Materials,General Materials Science

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3