Gadolinium (III)‐Chelated Deformable Mesoporous Organosilica Nanoparticles as Magnetic Resonance Imaging Contrast Agent

Author:

Chen Xiangyu123ORCID,Teng Shiyong2,Li Jinming3,Qiao Xuezhi3,Zhao Weidong3,Xue Zhengjie13,Shi Xudong4,Wang Yuguang5,Yang Wensheng2,Wang Tie13ORCID

Affiliation:

1. Life and Health Intelligent Research Institute Tianjin University of Technology Tianjin 300384 P. R. China

2. State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of Chemistry Jilin University Changchun 130022 P. R. China

3. Beijing National Laboratory for Molecular Sciences Key Laboratory of Analytical Chemistry for Living Biosystems Institute of Chemistry Chinese Academy of Sciences CAS Beijing 100049 P. R. China

4. NHC Key Laboratory of Human Disease Comparative Medicine Institute of Laboratory Animal Sciences Peking Union Medicine College Chinese Academy of Medical Sciences Beijing 100021 P. R. China

5. Center of Digital Dentistry Peking University School and Hospital of Stomatology NHC Research Center of Engineering and Technology for Computerized Dentistry Beijing 100081 P. R. China

Abstract

AbstractMagnetic resonance imaging (MRI) contrast agents, such as Magnevist (Gd‐DTPA), are routinely used for detecting tumors at an early stage. However, the rapid clearance by the kidney of Gd‐DTPA leads to short blood circulation time, which limits further improvement of the contrast between tumorous and normal tissue. Inspired by the deformability of red blood cells, which improves their blood circulation, this work fabricates a novel MRI contrast agent by incorporating Gd‐DTPA into deformable mesoporous organosilica nanoparticles (D‐MON). In vivo distribution shows that the novel contrast agent is able to depress rapid clearance by the liver and spleen, and the mean residence time is 20 h longer than Gd‐DTPA. Tumor MRI studies demonstrated that the D‐MON‐based contrast agent is highly enriched in the tumor tissue and achieves prolonged high‐contrast imaging. D‐MON significantly improves the performance of clinical contrast agent Gd‐DTPA, exhibiting good potential in clinical applications.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Chinese Academy of Sciences

China Postdoctoral Science Foundation

Publisher

Wiley

Subject

Mechanical Engineering,Mechanics of Materials,General Materials Science

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