Affiliation:
1. Department of Materials Department of Bioengineering Imperial College London SW7 2AZ London UK
Abstract
AbstractRaman spectroscopy is an analytical method based on light–matter interactions that can interrogate the vibrational modes of matter and provide representative molecular fingerprints. Mediated by its label‐free, non‐invasive nature, and high molecular specificity, Raman‐based techniques have become ubiquitous tools for in situ characterization of materials. This review comprehensively describes the theoretical and practical background of Raman spectroscopy and its advanced variants. The numerous facets of material characterization that Raman scattering can reveal, including biomolecular identification, solid‐to‐solid phase transitions, and spatial mapping of biomolecular species in bioactive materials, are highlighted. The review illustrates the potential of these techniques in the context of active biomedical material design and development by highlighting representative studies from the literature. These studies cover the use of Raman spectroscopy for the characterization of both natural and synthetic biomaterials, including engineered tissue constructs, biopolymer systems, ceramics, and nanoparticle formulations, among others. To increase the accessibility and adoption of these techniques, the present review also provides the reader with practical recommendations on the integration of Raman techniques into the experimental laboratory toolbox. Finally, perspectives on how recent developments in plasmon‐ and coherently‐enhanced Raman spectroscopy can propel Raman from underutilized to critical for biomaterial development are provided.
Funder
Engineering and Physical Sciences Research Council
Danmarks Frie Forskningsfond
Royal Academy of Engineering
Subject
Mechanical Engineering,Mechanics of Materials,General Materials Science
Cited by
1 articles.
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