Affiliation:
1. Department of Chemistry and The N.1 Institute for Health National University of Singapore Singapore 117543 Singapore
2. Paul C. Lauterbur Research Center for Biomedical Imaging Key Laboratory for Magnetic Resonance and Multimodality Imaging of Guangdong Province Shenzhen Key Laboratory of Ultrasound Imaging and Therapy CAS key laboratory of health informatics Institute of Biomedical and Health Engineering Shenzhen Institute of Advanced Technology Chinese Academy of Sciences Shenzhen 518055 P. R. China
Abstract
AbstractLanthanide‐based NIR‐IIb nanoprobes are ideal for in vivo imaging. However, existing NIR‐IIb nanoprobes often suffer from low tumor‐targeting specificity, limiting their widespread use. Here the application of bioorthogonal nanoprobes with high tumor‐targeting specificity for in vivo NIR‐IIb luminescence imaging and magnetic resonance imaging (MRI) is reported. These dual‐modality nanoprobes can enhance NIR‐IIb emission by 20‐fold and MRI signal by twofold, compared with non‐bioorthogonal nanoprobes in murine subcutaneous tumors. Moreover, these bioorthogonal probes enable orthotopic brain tumor imaging. Implementation of bio‐orthogonal chemistry significantly reduces the nanoprobe dose and hence cytotoxicity, providing a paradigm for real‐time in vivo visualization of tumors.
Funder
National Natural Science Foundation of China
Agency for Science, Technology and Research
Key Laboratory for Magnetic Resonance and Multimodality Imaging of Guangdong Province
Cited by
68 articles.
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