Affiliation:
1. Chongqing Key Laboratory of Oral Disease and Biomedical Sciences Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education Stomatological Hospital of Chongqing Medical University Chongqing 401174 P. R. China
2. The People's Hospital of Kaizhou District Chongqing 405499 P. R. China
3. Division of Engineering in Medicine Department of Medicine Brigham and Women's Hospital Harvard Medical School Cambridge MA 02139 USA
Abstract
AbstractTissue adhesives are promising alternatives to sutures and staples to achieve wound closure and hemostasis. However, they often do not work well on tissues that are soaked in blood or other biological fluids, and organs that are typically exposed to a variety of harsh environments such as different pH values, nonhomogeneous distortions, continuous expansions and contractions, or high pressures. In this study, a nature‐derived multilayered hetero‐bioadhesive patch (skin secretion of Andrias davidianus (SSAD)‐Patch) based on hydrophilic/hydrophobic pro‐healing bioadhesives derived from the SSAD is developed, which is designed to form pressure‐triggered strong adhesion with wet tissues. The SSAD‐Patch is successfully applied for the sealing and healing of tissue defects within 10 s in diverse extreme injury scenarios in vivo including rat stomach perforation, small intestine perforation, fetal membrane defect, porcine carotid artery incision, and lung lobe laceration. The findings reveal a promising new type of self‐adhesive regenerative SSAD‐Patch, which is potentially adaptable to broad applications (under different pH values and air or liquid pressures) in sutureless wound sealing and healing.
Funder
National Natural Science Foundation of China
National Key Research and Development Program of China
Brigham Research Institute