Engineered Hierarchical Microdevices Enable Pre‐Programmed Controlled Release for Postsurgical and Unresectable Cancer Treatment

Author:

Wu Lihuang1ORCID,Li Junhua1,Wang Yuqi1,Zhao Xinyue1,He Yiyan1ORCID,Mao Hongli12,Tang Wenbo3,Liu Rong3,Luo Kui4ORCID,Gu Zhongwei134ORCID

Affiliation:

1. Research Institute for Biomaterials Tech Institute for Advanced Materials Bioinspired Biomedical Materials & Devices Center College of Materials Science and Engineering Jiangsu Collaborative Innovation Center for Advanced Inorganic Function Composites Suqian Advanced Materials Industry Technology Innovation Center Nanjing Tech University Nanjing 211816 China

2. NJTech‐BARTY Joint Research Center for Innovative Medical Technology Nanjing Tech University Nanjing 210009 China

3. Faculty of Hepatopancreatobiliary Surgery the First Medical Center Chinese PLA General Hospital Beijing 100039 China

4. Department of Radiology Huaxi MR Research Center (HMRRC) National Clinical Research Center for Geriatrics Frontiers Science Center for Disease‐Related Molecular Network State Key Laboratory of Biotherapy West China Hospital Sichuan University Chengdu 610041 China

Abstract

AbstractDrug treatment is required for both resectable and unresectable cancers to strive for any meaningful improvement in patient outcomes. However, the clinical benefit of receiving conventional systemic administrations is often less than satisfactory. Drug delivery systems are preferable substitutes but still fail to meet diverse clinical demands due to the difficulty in programming drug release profiles. Herein, a microfabrication concept, termed “Hierarchical Multiple Polymers Immobilization” (HMPI), is introduced and biodegradable‐polymer‐based hierarchical microdevices (HMDs) that can pre‐program any desired controlled release profiles are engineered. Based on the first‐line medication of pancreatic and breast cancer, controlled release of single gemcitabine and the doxorubicin/paclitaxel combination in situ for multiple courses is implemented, respectively. Preclinical models of postsurgical pancreatic, postsurgical breast, and unresectable breast cancer are established, and the designed HMDs are demonstrated as well‐tolerable and effective treatments for inhibiting tumor growth, recurrence, and metastasis. The proposed HMPI strategy allows the creation of tailorable and high‐resolution hierarchical microstructures for pre‐programming controlled release according to clinical medication schedules, which may provide promising alternative treatments for postsurgical and unresectable tumor control.

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Publisher

Wiley

Subject

Mechanical Engineering,Mechanics of Materials,General Materials Science

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