Affiliation:
1. Institute of Nano Biomedicine and Engineering Shanghai Engineering Research Center for Intelligent Diagnosis and Treatment Instrument Department of Instrument Science and Engineering School of Electronic Information and Electrical Engineering Shanghai Jiao Tong University 800 Dongchuan RD Shanghai 200240 P. R. China
2. National Center for Translational Medicine Collaborative Innovational Center for System Biology Shanghai Jiao Tong University 800 Dongchuan Road Shanghai 200240 P. R. China
3. Institute of Nano Science and Technology University of Zaragoza Zaragoza 50018 Spain
Abstract
AbstractNanozymes with inherent enzyme‐mimicking catalytic properties combat malignant tumor progression via catalytic therapy, while the therapeutic efficacy still needs to be improved. In this work, ultrasmall platinum nanozymes (nPt) in a confined domain of a wormlike pore channel in gold nanobipyramidal–mesoporous silica dioxide nanocomposites, producing nanozyme carriers AP‐mSi with photoenhanced peroxidase ability, are innovatively synthesized. Afterward, based on the prepared AP‐mSi, a lung‐cancer nanozymes probe (AP‐HAI) is ingeniously produced by removing the SiO2 template, modifying human serum albumin, and loading atovaquone molecules (ATO) as well as IR780. Under NIR light irradiation, inner AuP and IR780 collaborate for photothermal process, thus facilitating the peroxidase‐like catalytic process of H2O2. Additionally, loaded ATO, a cell respiration inhibitor, can impair tumor respiration metabolism and cause oxygen retention, hence enhancing IR780's photodynamic therapy (PDT) effectiveness. As a result, IR780's PDT and nPt nanozymes' photoenhanced peroxidase‐like ability endow probes a high ROS productivity, eliciting antitumor immune responses to destroy tumor tissue. Systematic studies reveal that the obvious reactive oxygen species (ROS) generation is obtained by the strategy of using nPt nanozymes and reducing oxygen consumption by ATO, which in turn enables lung‐cancer synergetic catalytic therapy/immunogenic‐cell‐death‐based immunotherapy. The results of this work would provide theoretical justification for the practical use of photoenhanced nanozyme probes.
Funder
National Natural Science Foundation of China
National Key Research and Development Program of China
Natural Science Foundation of Shanghai Municipality
China Postdoctoral Science Foundation
Subject
Mechanical Engineering,Mechanics of Materials,General Materials Science
Cited by
1 articles.
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