IDentif . AI : Rapidly optimizing combination therapy design against severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐Cov‐2) with digital drug development

Author:

Blasiak Agata123ORCID,Lim Jhin Jieh4,Seah Shirley Gek Kheng5,Kee Theodore123ORCID,Remus Alexandria123ORCID,Chye De Hoe5,Wong Pui San5,Hooi Lissa4,Truong Anh T. L.123ORCID,Le Nguyen123ORCID,Chan Conrad E. Z.5,Desai Rishi6,Ding Xianting7,Hanson Brendon J.5,Chow Edward Kai‐Hua12348,Ho Dean1238ORCID

Affiliation:

1. The N.1 Institute for Health (N.1) National University of Singapore Singapore Singapore

2. The Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore

3. Department of Biomedical Engineering, NUS Engineering National University of Singapore Singapore Singapore

4. Cancer Science Institute of Singapore National University of Singapore Singapore Singapore

5. Defence Medical and Environmental Research Institute DSO National Laboratories Singapore Singapore

6. Osmosis Baltimore Maryland USA

7. Institute for Personalized Medicine, School of Biomedical Engineering Shanghai Jiao Tong University Shanghai China

8. Department of Pharmacology, Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore

Funder

National Basic Research Program of China

National Research Foundation Singapore

National Natural Science Foundation of China

Micron Foundation

Publisher

Wiley

Subject

Pharmaceutical Science,Biomedical Engineering,Biotechnology

Reference60 articles.

1. A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19

2. Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial

3. Compassionate Use of Remdesivir for Patients with Severe Covid-19

4. NIH.NIH clinical trial shows Remdesivir accelerates recovery from advanced COVID‐19. NIH.https://www.nih.gov/news-events/news-releases/nih-clinical-trial-shows-remdesivir-accelerates-recovery-advanced-covid-19. Accessed 29 Apr 2020

5. Experimental Treatment with Favipiravir for COVID-19: An Open-Label Control Study

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