A robust, accurate, sensitive LC–MS/MS method to measure indoxyl sulfate, validated for plasma and kidney cells

Author:

Ahmed Sabbir1ORCID,Sparidans Rolf W.1,Lu Jingyi1,Mihaila Silvia M.12,Gerritsen Karin G. F.2,Masereeuw Rosalinde1ORCID

Affiliation:

1. Division of Pharmacology, Department of Pharmaceutical Sciences, Utrecht Institute for Pharmaceutical Sciences Utrecht University Utrecht The Netherlands

2. Department of Nephrology and Hypertension University Medical Center Utrecht Utrecht The Netherlands

Publisher

Wiley

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry

Reference37 articles.

1. An Oral Adsorbent Downregulates Renal Expression of Genes That Promote Interstitial Inflammation and Fibrosis in Diabetic Rats

2. Serum Indoxyl Sulfate Is Associated with Vascular Disease and Mortality in Chronic Kidney Disease Patients

3. Next-generation biomarkers for detecting kidney toxicity

4. Center for Drug Evaluation and Research &Center for Veterinary Medicine. (2020).Bioanalytical Method Validation Guidance for Industry. Accessed August 19 2020.https://www.fda.gov/regulatory-information/search-fda-guidance-documents/bioanalytical-method-validation-guidance-industry

5. Matrix Effects—A Challenge Toward Automation of Molecular Analysis

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