The current drug discovery landscape for trypanosomiasis and leishmaniasis: Challenges and strategies to identify drug targets

Author:

Altamura Fernando1ORCID,Rajesh Rishi1ORCID,Catta-Preta Carolina M. C.2ORCID,Moretti Nilmar S.3ORCID,Cestari Igor1ORCID

Affiliation:

1. Institute of Parasitology; McGill University; Ste Anne de Bellevue Quebec Canada

2. Structural Genomics Consortium; Universidade Estadual de Campinas-UNICAMP; Campinas SP Brazil

3. Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina; Universidade Federal de São Paulo; São Paulo SP Brazil

Funder

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Fundação de Amparo à Pesquisa do Estado de São Paulo

Natural Sciences and Engineering Research Council of Canada

Publisher

Wiley

Subject

Drug Discovery

Reference193 articles.

1. A genomic scale map of genetic diversity in Trypanosoma cruzi;Ackermann;BMC Genomics,2012

2. Lactose derivatives are inhibitors of Trypanosoma cruzi trans-sialidase activity toward conventional substrates in vitro and in vivo;Agusti;Glycobiology,2004

3. Challenges in drug discovery targeting TriTryp diseases with an emphasis on leishmaniasis;Alcantara;International Journal for Parasitology: Drugs and Drug Resistance,2018

4. High-throughput decoding of antitrypanosomal drug efficacy and resistance;Alsford;Nature,2012

5. High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome;Alsford;Genome Research,2011

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