Testing for the indirect effect under the null for genome-wide mediation analyses

Author:

Barfield Richard1ORCID,Shen Jincheng1,Just Allan C.2,Vokonas Pantel S.3,Schwartz Joel4,Baccarelli Andrea A.5,VanderWeele Tyler J.16,Lin Xihong17

Affiliation:

1. Department of Biostatistics; Harvard T.H. Chan School of Public Health; Harvard University; Boston Massachusetts United States of America

2. Department of Environmental Medicine & Public Health; Icahn School of Medicine at Mount Sinai; New York City New York United States of America

3. VA Normative Aging Study; Veterans Affairs Boston Healthcare System, The Department of Medicine; Boston University School of Medicine; Boston Massachusetts United States of America

4. Departments of Environmental Health and Program in Quantitative Genomics; Harvard T.H. Chan School of Public Health; Harvard University; Boston Massachusetts United States of America

5. Departments of Environmental Health Sciences and Epidemiology; Columbia University Mailman School of Public Health; New York City New York United States of America

6. Department of Epidemiology; Harvard T.H. Chan School of Public Health; Harvard University; Boston Massachusetts United States of America

7. Department of Statistics; Harvard University; Cambridge Massachusetts United States of America

Funder

Clinical Science R&D Service

National Cancer Institute

National Human Genome Research Institute

National Institute of Environmental Health Sciences

National Institute of General Medical Sciences

National Heart, Lung, and Blood Institute

Cooperative Studies Program/Epidemiology Research and Information Center

Massachusetts Veterans Epidemiology Research and Information Center

Publisher

Wiley

Subject

Genetics (clinical),Epidemiology

Reference47 articles.

1. The probability function of the product of two normally distributed variables;Aroian;The Annals of Mathematical Statistics,1947

2. DNA methylation changes measured in pre-diagnostic peripheral blood samples are associated with smoking and lung cancer risk;Baglietto;International Journal of Cancer,2017

3. The moderator-mediator variable distinction in social psychological research: Conceptual, strategic, and statistical considerations;Baron;Journal of Personality and Social Psychology,1986

4. P values for composite null models;Bayarri;Journal of the American Statistical Association,2000

5. The Normative Aging Study: An interdisciplinary and longitudinal study of health and aging;Bell;International Journal of Aging and Human Development,1972

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