Investigating the Heterogeneity of “Study Twins”

Author:

Röver Christian1ORCID,Friede Tim12ORCID

Affiliation:

1. Department of Medical Statistics University Medical Center Göttingen Göttingen Germany

2. DZHK (German Center for Cardiovascular Research), partner site Göttingen Göttingen Germany

Abstract

ABSTRACTMeta‐analyses are commonly performed based on random‐effects models, while in certain cases one might also argue in favor of a common‐effect model. One such case may be given by the example of two “study twins” that are performed according to a common (or at least very similar) protocol. Here we investigate the particular case of meta‐analysis of a pair of studies, for example, summarizing the results of two confirmatory clinical trials in phase III of a clinical development program. Thereby, we focus on the question of to what extent homogeneity or heterogeneity may be discernible and include an empirical investigation of published (“twin”) pairs of studies. A pair of estimates from two studies only provide very little evidence of homogeneity or heterogeneity of effects, and ad hoc decision criteria may often be misleading.

Funder

Deutsche Forschungsgemeinschaft

Publisher

Wiley

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3