Lung T1 MRI assessments in children with mild cystic fibrosis lung disease

Author:

Ren Clement L.12ORCID,Nasr Samya Z.3,Slaven James E.4,Joshi Aparna3,Mahani Maryam Ghadimi35,Clem Charles6,Cooper Matthew6,Farr Susan7,MacAskill Christina J.7,Keshock Elise7,Nicholas Jennifer L.8,Ferrebee Matthew8,McBennett Kimberly78ORCID,Flask Chris A.7

Affiliation:

1. Division of Pulmonary and Sleep Medicine Children's Hospital of Philadelphia Philadelphia Pennsylvania USA

2. Department of Pediatrics, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA

3. Department of Pediatrics, Michigan Medicine University of Michigan Ann Arbor Michigan USA

4. Department of Pediatrics Indiana University School of Medicine Indianapolis Indiana USA

5. Advanced Radiology Services Lansing Michigan USA

6. Division of Pulmonary, Allergy, and Sleep Medicine Riley Hospital for Children Indianapolis Indiana USA

7. Imaging Research Core Case Western Reserve University Cleveland Ohio USA

8. Department of Radiology, Rainbow Babies and Children's Hospital University Hospitals ‐ Cleveland Medical Center Cleveland Ohio USA

Abstract

AbstractRationaleLung T1 MRI is a potential method to assess cystic fibrosis (CF) lung disease that is safe, quick, and widely available, but there are no data in children with mild CF lung disease.ObjectiveAssess the ability of lung T1 MRI to detect abnormalities in children with mild CF lung disease.MethodsWe performed T1 MRI, multiple breath washout (MBW), chest computed tomography (CT), and spirometry in a cohort of 45 children with mild CF lung disease (6–11 years of age).Main ResultsDespite mean normal ppFEV1 values, the majority of children with CF in this study exhibited mild lung disease evident in lung clearance index (LCI) measured by MBW, chest CT Brody scores, and percent normal lung perfusion (%NLP) measured by T1 MRI. The %NLP correlated with chest CT Brody scores, as did LCI, but %NLP and LCI did not correlate with each other. Analysis of the Brody subscores showed that %NLP and LCI largely correlated with different Brody subscores.ConclusionsT1 MRI can detect mild CF lung disease in children and correlates with chest CT findings. The %NLP from T1 MRI and LCI correlate with different chest CT Brody subscores, suggesting they provide complementary information about CF lung disease.

Funder

Cystic Fibrosis Foundation

Publisher

Wiley

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