pH and excipient profiles during formulation of highly concentrated biotherapeutics using bufferless media
Author:
Affiliation:
1. Department of Chemical Engineering The Pennsylvania State University University Park Pennsylvania
2. Eli Lilly and Company Indianapolis Indiana
Funder
Eli Lilly and Company
Publisher
Wiley
Subject
Applied Microbiology and Biotechnology,Bioengineering,Biotechnology
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/bit.27502
Reference20 articles.
1. A Small-Scale Process for Predicting Donnan and Volume Exclusion Effects During Ultrafiltration/Diafiltration Process Development
2. Mass Balance Model with Donnan Equilibrium Accurately Describes Unusual pH and Excipient Profiles during Diafiltration of Monoclonal Antibodies
3. pH variations during diafiltration due to buffer nonidealities
4. Buffer-free therapeutic antibody preparations provide a viable alternative to conventionally buffered solutions: From protein buffer capacity prediction to bioprocess applications
5. Membrane ultrafiltration: The diafiltration technique and its application to microsolute exchange and binding phenomena
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