Promoter optimisation of lentiviral vectors for efficient insulin gene expression in canine mesenchymal stromal cells: potential surrogate beta cells

Author:

Gautam Pratigya1,Recino Asha2,Foale Robert D.3,Zhao Jing1,Gan Shu Uin4,Wallberg Maja3,Calne Roy5,Lever Andrew M.L.1

Affiliation:

1. Department of Medicine; University of Cambridge; Cambridge UK

2. Department of Pathology; University of Cambridge; Cambridge UK

3. Dick White Referrals; Station Farm; Six Mile Bottom Suffolk UK

4. Department of Surgery; National Institute of Singapore; Singapore

5. Department of Surgery; University of Cambridge; Cambridge UK

Publisher

Wiley

Subject

Genetics (clinical),Drug Discovery,Genetics,Molecular Biology,Molecular Medicine

Reference48 articles.

1. World Health Organisation and International Diabetes Foundation Definition and Diagnosis of Diabetes Mellitus and Intermediate Hyperglycaemia WHO Document Production Services Geneva, Switzerland

2. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen;Shapiro;N Engl J Med,2000

3. Type 1 diabetes: new perspectives on disease pathogenesis and treatment;Atkinson;Lancet,2001

4. Insulin expressed from endogenously active glucose-responsive EGR1 promoter in bone marrow mesenchymal stromal cells as diabetes therapy;Chen;Gene Ther,2010

5. Treatment of diabetes and long-term survival after insulin and glucokinase gene therapy;Callejas;Diabetes,2013

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