The kynurenine pathway is activated in human obesity and shifted toward kynurenine monooxygenase activation

Author:

Favennec Marie12345,Hennart Benjamin256,Caiazzo Robert2457,Leloire Audrey1234,Yengo Loïc1234,Verbanck Marie1234,Arredouani Abdelilah8,Marre Michel9,Pigeyre Marie2457,Bessede Alban10,Guillemin Gilles J.11,Chinetti Giulia23412,Staels Bart23412,Pattou François2457,Balkau Beverley13,Allorge Delphine256,Froguel Philippe123414,Poulain-Godefroy Odile1234

Affiliation:

1. CNRS UMR 8199; Lille France

2. University of Lille; Lille France

3. Institut Pasteur De Lille; Lille France

4. European Genomic Institute for Diabetes (EGID); Lille France

5. CHRU De Lille; Lille France

6. EA4483; Lille France

7. INSERM UMR 1190; Lille France

8. Qatar Biomedical Research Institute, Qatar Foundation; Doha Qatar

9. INSERM U872; Paris France

10. Immusmol; Pessac France

11. Neuroinflammation Group, Macquarie University, Sydney; New South Wales Australia

12. INSERM UMR 1011; Lille France

13. INSERM UMRS 1018; Villejuif France

14. CHRU De Lille; Lille France. Department of Genomics of Common Disease; School of Public Health, Imperial College London; London UK.

Funder

The CNRS, The Société Francophone du Diabète, European Genomic Institute for Diabetes

Inserm contracts with CNAMTS, Lilly, Novartis Pharma, and Sanofi-aventis, as well as Inserm (Réseaux en Santé Publique, Interactions entre les déterminants de la santé, Cohortes Santé TGIR 2008)

Publisher

Wiley

Subject

Nutrition and Dietetics,Endocrinology,Endocrinology, Diabetes and Metabolism,Medicine (miscellaneous)

Reference39 articles.

1. Kynurenines in CNS disease: regulation by inflammatory cytokines;Campbell;Front Neurosci,2014

2. Characterization of an indoleamine 2,3-dioxygenase-like protein found in humans and mice;Ball;Gene,2007

3. Tryptophan metabolism activation by indoleamine 2,3-dioxygenase in adipose tissue of obese women: an attempt to maintain immune homeostasis and vascular tone;Wolowczuk;AJP Regul Integr Comp Physiol,2012

4. Decreased serum tryptophan in patients with HIV-1 infection correlates with increased serum neopterin and with neurologic/psychiatric symptoms;Fuchs;J Acquir Immune Defic Syndr,1990

5. Bariatric surgery cannot prevent tryptophan depletion due to chronic immune activation in morbidly obese patients;Brandacher;Obes Surg,2006

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