Glucosamine conjugated iron oxide and graphene oxide nanohybrid for smart drug delivery

Author:

Mousavi Maedehsadat1,Salehi Zeinab1,Rezvanpour Alireza2,Mosayebi Mehdi1,Farahani Masoumeh3,Asadi Tokmedash Mohammad1,Shokrgozar Mohammad Ali4

Affiliation:

1. School of Chemical Engineering, College of Engineering University of Tehran Tehran Iran

2. Department of Mechanical and Aerospace Engineering Carleton University Ottawa Ontario Canada

3. Proteomics Research Center Shahid Beheshti University of Medical Sciences Tehran Iran

4. New Research Technologies Group and Research Director Pasteur Institute of Iran (IPI), National Cell Bank of Iran Tehran Iran

Abstract

AbstractSmart drug delivery systems have attracted a lot of attention as one of the new treatment methods for cancer. In this study, a smart drug delivery system carrying anticancer drugs was obtained by the intelligent synthesis of glucosamine (GA)‐functionalized graphene oxide (GO)‐based iron oxide nanoparticles (Fe3O4@GO‐GA) using Hummers and chemical co‐precipitation processes. Nanohybrids have a high surface area (280.26 m2/g) and superparamagnetic behaviour (Ms = 26.017 emu/g), indicating a significant loading capacity (373.78 mg/mg) and efficiency (96.3%) for pharmaceutical loading. An adsorption study of conventional daunorubicin (DNR) on this carrier showed that the drug release is more prone to occur under acidic conditions (pH = 5.5), at moderately high temperatures (T = 40°C), and in the absence of smart carriers. The toxicity of the smart nanohybrids was examined using the sulphorhodamine B (SRB) assay in Michigan Cancer Foundation‐7 (MCF‐7) cell lines. The rate of death of cells exposed to smart drug‐containing systems in comparison to the systems without GA shows that GA reduces the toxicity of Fe3O4@GO.

Publisher

Wiley

Subject

General Chemical Engineering

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