Why Most Acute Stroke Studies Are Positive in Animals but Not in Patients: A Systematic Comparison of Preclinical, Early Phase, and Phase 3 Clinical Trials of Neuroprotective Agents
Author:
Affiliation:
1. Department of NeurologyInstitute of Translational Neurology, University of Münster Münster
2. Institute of Epidemiology and Social MedicineUniversity of Münster Münster
3. Department of NeurologyEvangelical Hospital Bethel Bielefeld Germany
Funder
Else Kröner-Fresenius-Stiftung
Deutsche Forschungsgemeinschaft
Publisher
Wiley
Subject
Neurology (clinical),Neurology
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/ana.25643
Reference21 articles.
1. Heart Disease and Stroke Statistics—2017 Update: A Report From the American Heart Association
2. 2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association
3. 1,026 Experimental treatments in acute stroke
4. Translating animal research into clinical benefit
5. Translation of Research Evidence From Animals to Humans
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