Risk factors for local recurrence of upper extremity desmoid tumors

Author:

Denwood Hayley12,Gonzalez Marcos R.1ORCID,Sodhi Alisha1,Werenski Joseph1,Clunk Marilee13,Newman Erik T.1,Lozano‐Calderón Santiago A.1ORCID

Affiliation:

1. Department of Orthopaedic Surgery Harvard Medical School, Division of Orthopaedic Oncology, Massachusetts General Hospital Boston Massachusetts USA

2. Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA

3. University of Toledo College of Medicine and Life Sciences Toledo Toledo Ohio USA

Abstract

AbstractIntroductionUpper extremity (UE) desmoid tumors are locally aggressive neoplasms with high recurrence rates. Our study sought to analyze the demographics and treatment strategies of UE desmoid tumors and identify risk factors for recurrence.Materials and MethodsA retrospective review of 52 patients with histologically confirmed UE desmoid tumors treated at our institution between 1990 and 2015 was conducted. Survival was assessed using the Kaplan–Meier method and the Cox proportional hazards model was used for risk factor analysis.ResultsFor the entire cohort, median age was 40 (29–47) years, 75% were female, and 48% had local recurrence. The median tumor size was 45 (15–111) cm3 on imaging. Twenty‐two patients had a previous resection. The most common treatments were surgery alone (50%) and surgery with adjuvant radiotherapy (21%). Tumor size ≥5 cm and tumor volume ≥40 cm3 on imaging were associated with increased recurrence (p = 0.006 and p = 0.005, respectively). Age and sex were not associated with local recurrence. Patients with a tumor size ≥5 cm were 2.6 times more likely to present with recurrence. At the 10‐year mark, a lower local recurrence‐free survival was seen in patients with tumors ≥5 cm (72.2% vs. 36.3%, p = 0.042) or ≥40 cm3 (67.2% vs. 32.7%, p = 0.034).ConclusionIn our study, only tumor dimensions appeared to modify recurrence risk.

Publisher

Wiley

Subject

Oncology,General Medicine,Surgery

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