Impinging jet mixers: A review of their mixing characteristics, performance considerations, and applications

Author:

Devos Cedric1ORCID,Mukherjee Saikat1,Inguva Pavan1,Singh Shalini1,Wei Yi2,Mondal Sandip3,Yu Huiwen1,Barbastathis George23,Stelzer Torsten145,Braatz Richard D.1,Myerson Allan S.1ORCID

Affiliation:

1. Department of Chemical Engineering Massachusetts Institute of Technology Cambridge Massachusetts USA

2. Department of Mechanical Engineering Massachusetts Institute of Technology Cambridge Massachusetts USA

3. Singapore‐MIT Alliance for Research and Technology (SMART) Centre Singapore

4. Department of Pharmaceutical Sciences, School of Pharmacy University of Puerto Rico ‐ Medical Sciences Campus San Juan Puerto Rico

5. Crystallization Design Institute, Molecular Sciences Research Center University of Puerto Rico San Juan Puerto Rico

Abstract

AbstractOptimal control over fast chemical processes hinges on the achievement of rapid and effective mixing. Impinging jet mixers are a unique class of passive mixing devices renowned for their exceptional ability to achieve rapid mixing at micro‐length scales, whilst offering the possibility of a high throughput. Comprising of two co‐linear jets flowing in opposite directions and colliding with each other within a small (usually confined) volume, these devices effectively intensify various mixing‐controlled processes in a reproducible manner. Impinging jet mixers find extensive use in both the chemical and pharmaceutical industry for a plethora of applications, such as reaction injection molding and precipitation processes. This review provides an overview of research related to impinging jet mixers, with an emphasis on the mixing characteristics and the influence of design and process parameters on the mixing performance. Lastly, specific applications for which these devices are exceptionally suited are discussed.

Funder

U.S. Food and Drug Administration

Publisher

Wiley

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