Affiliation:
1. Department of Pediatrics Children's Hospital of Colorado Aurora Colorado USA
2. Department of Pediatric University of Cincinnati College of Medicine Cincinnati Ohio USA
3. Division of Oncology Cincinnati Children's Hospital Cincinnati Ohio USA
Abstract
AbstractPost‐transplant lymphoproliferative disease (PTLD) remains a major complication of transplantation. PTLD is a rare entity and very heterogenous making consensus on diagnosis and treatment very challenging. The majority are Epstein‐Barr virus (EBV) driven, CD20+ B‐cell proliferations. PTLD does occur following hematopoietic stem cell transplant (HSCT), but due to the relative short risk period and efficacy of pre‐emptive therapy, PTLD following HSCT will not be discussed in this review. This review will focus on the epidemiology, role of EBV, clinical presentation, diagnosis and evaluation and the current and emerging treatment strategies for pediatric PTLD following solid organ transplantation.
Subject
Cancer Research,Oncology,Hematology,General Medicine
Cited by
5 articles.
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